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dc.creatorMussazhanova, Zhanna
dc.creatorMatsuda, Katsuya
dc.creatorNaruke, Yuki
dc.creatorMitsutake, Norisato
dc.creatorStanojević, Boban
dc.creatorRougounovitch, Tatiana
dc.creatorSaenko, Vladimir
dc.creatorSuzuki, Keiji
dc.creatorNishihara, Eijyun
dc.creatorHirokawa, Mitsuyoshi
dc.creatorIto, Masahiro
dc.creatorNakashima, Masahiro
dc.date.accessioned2018-03-01T23:44:33Z
dc.date.available2018-03-01T23:44:33Z
dc.date.issued2013
dc.identifier.issn0309-0167 (print)
dc.identifier.issn1365-2559 (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/5717
dc.description.abstractAimsIn a previous report, we proposed that analysis of 53BP1 expression by immunofluorescence could be a useful tool in estimating the level of genomic instability (GIN), as well as the malignant potential, of thyroid tumours. In an attempt to clarify the value of 53BP1 expression as a new molecular marker for the aggressiveness of thyroid papillary microcarcinoma (PMC), we assessed the association between the type of 53BP1 expression and clinicopathological features such as tumour size, extrathyroidal invasion, lymph node metastasis and BRAF(V600E) mutation of PMC. Methods and resultsA total of 36 surgically resected thyroid tumours, including 13 PMC and 23 conventional papillary thyroid carcinomas (PTC), were available for this study. Analysis using immunofluorescence revealed that the incidence of an abnormal or high DNA damage response (DDR) type of 53BP1 expression was significantly higher in PTC than PMC. BRAF(V600E) mutation was not associated significantly with tumour aggressiveness in either PMC or PTC cases. Abnormal/high DDR type of 53BP1 expression was associated closely with both BRAF(V600E) mutation and papillary and/or trabecular architecture of PMC. ConclusionsAbnormal/high DDR type of 53BP1 expression might be associated with GIN and papillary/trabecular morphology at an early stage of PTC carcinogenesis through BRAF(V600E) mutation.en
dc.relationNagasaki University Global Center of Excellence (COE), Japanese Ministry of Education, Science, Sports and Culture [24590414]
dc.rightsrestrictedAccessen
dc.sourceHistopathologyen
dc.subject53BP1en
dc.subjectBRAFen
dc.subjectgenomic instabilityen
dc.subjectimmunofluorescenceen
dc.subjectthyroid papillary microcarcinomaen
dc.titleSignificance of p53-binding protein 1 (53BP1) expression in thyroid papillary microcarcinoma: association with BRAF(V600E) mutation statusen
dc.typearticleen
dcterms.abstractМуссазханова, Зханна; Матсуда, Катсуyа; Наруке, Yуки; Роугоуновитцх, Татиана; Саенко, Владимир; Сузуки, Кеији; Нисхихара, Еијyун; Станојевић Бобан; Митсутаке, Норисато; Ито, Масахиро; Накасхима, Масахиро; Хирокаwа, Митсуyосхи;
dc.citation.volume63
dc.citation.issue5
dc.citation.spage726
dc.citation.epage734
dc.identifier.wos000325545600013
dc.identifier.doi10.1111/his.12233
dc.citation.rankM21
dc.identifier.pmid24004175
dc.identifier.scopus2-s2.0-84885432843


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