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Atomic Force Microscopy Characterization of the External Cortical Bone Surface in Young and Elderly Women: Potential Nanostructural Traces of Periosteal Bone Apposition During Aging
dc.creator | Milovanović, Petar | |
dc.creator | Đurić, Marija | |
dc.creator | Nešković, Olivera M. | |
dc.creator | Djonic, Danijela | |
dc.creator | Potočnik, Jelena | |
dc.creator | Nikolic, Slobodan | |
dc.creator | Stoiljković, Milovan | |
dc.creator | Živković, Vladimir | |
dc.creator | Rakočević, Zlatko Lj. | |
dc.date.accessioned | 2018-03-01T23:41:56Z | |
dc.date.available | 2018-03-01T23:41:56Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 1431-9276 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/5687 | |
dc.description.abstract | On the basis of the suggestion that bone nanostructure bears tissue age information and may reflect surface deposition/modification processes, we performed nanoscale characterization of the external cortical bone surface at the femoral neck in women using atomic force microscopy (AFM). The specific aims were to assess age-related differences in bone nanostructure and explore the existence of nanostructural traces of potential bone apposition at this surface. Our findings revealed that the external cortical surface represents a continuous phase composed of densely packed mineral grains. Although the grains varied in size and shape, there was a domination of small grains indicative of freshly deposited bone (mean grain size: young, 35 nm; old, 37 nm; p. 0.05). Advanced quantitative analysis of surface morphological patterns revealed comparable roughness and complexity of the surface, suggesting a similar rate of mineral particle deposition at the surface in both groups. Calcium/phosphorus ratio, a measure of bone tissue age, was within the same range in both groups. In summary, our AFM analyses showed consistent nanostructural and compositional bone features, suggesting existence of new bone at the periosteal bone surface in both young and elderly women. Considering observed age-related increase in the neck diameter, AFM findings may support the theory of continuous bone apposition at the periosteal surface. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45005/RS// | |
dc.rights | restrictedAccess | en |
dc.source | Microscopy and Microanalysis | en |
dc.subject | atomic force microscopy (AFM) | en |
dc.subject | bone | en |
dc.subject | nanostructure | en |
dc.subject | periosteal surface | en |
dc.subject | aging | en |
dc.subject | femoral neck | en |
dc.title | Atomic Force Microscopy Characterization of the External Cortical Bone Surface in Young and Elderly Women: Potential Nanostructural Traces of Periosteal Bone Apposition During Aging | en |
dc.type | article | en |
dcterms.abstract | Несковиц, Оливера; Ракочевић Златко Љ.; Стоиљковић Милован; Поточник Јелена; Миловановиц, Петар; Николиц, Слободан; Зивковиц, Владимир; Дјуриц, Марија; Дјониц, Данијела; | |
dc.citation.volume | 19 | |
dc.citation.issue | 5 | |
dc.citation.spage | 1341 | |
dc.citation.epage | 1349 | |
dc.identifier.wos | 000324550900029 | |
dc.identifier.doi | 10.1017/S1431927613001761 | |
dc.citation.rank | M22 | |
dc.identifier.pmid | 23764147 | |
dc.identifier.scopus | 2-s2.0-84884546987 |
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