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Inhibitory effect of cisplatin and [Pt(dach)Cl2] on the activity of phospholipase A2
dc.creator | Radisavljevic, Maja | |
dc.creator | Kamceva, Tina | |
dc.creator | Bugarčić, Živadin D. | |
dc.creator | Petković, Marijana | |
dc.date.accessioned | 2018-03-01T23:33:01Z | |
dc.date.available | 2018-03-01T23:33:01Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 1475-6366 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/5583 | |
dc.description.abstract | This work has been focused on testing the influence of two selected Pt(II) complexes cisplatin, Pt(NH3)(2) Cl-2, and [Pt(dach)Cl-2] on the activity of porcine pancreatic phospholipase A(2) (PLA(2)). It has been assumed that this enzyme plays a role in carcinogenesis and that it could be a target in the tumour therapy. The results of this study show that both Pt(II) complexes inhibit the activity of the enzyme, though they bind to it in a different manner. While cisplatin interacts with the enzyme in an acompetitive manner, the stable interaction of [Pt(dach)Cl-2] with PLA(2) could not be detected under our experimental conditions. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172011/RS// | |
dc.rights | openAccess | en |
dc.source | Journal of Enzyme Inhibition and Medicinal Chemistry | en |
dc.subject | MALDI TOF MS | en |
dc.subject | metallo-drugs | en |
dc.subject | phosphatidylcholine | en |
dc.title | Inhibitory effect of cisplatin and [Pt(dach)Cl2] on the activity of phospholipase A2 | en |
dc.type | article | en |
dcterms.abstract | Петковић Маријана; Радисављевиц, Маја; Камцева, Тина; Бугарциц, Зивадин Д.; | |
dc.citation.volume | 28 | |
dc.citation.issue | 4 | |
dc.citation.spage | 651 | |
dc.citation.epage | 660 | |
dc.identifier.wos | 000321693400001 | |
dc.identifier.doi | 10.3109/14756366.2012.666539 | |
dc.citation.rank | M23 | |
dc.identifier.pmid | 22424180 | |
dc.identifier.scopus | 2-s2.0-84880057888 | |
dc.identifier.fulltext | https://vinar.vin.bg.ac.rs/bitstream/id/6329/bitstream_6329.pdf |