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dc.creatorRadisavljevic, Maja
dc.creatorKamceva, Tina
dc.creatorBugarčić, Živadin D.
dc.creatorPetković, Marijana
dc.date.accessioned2018-03-01T23:33:01Z
dc.date.available2018-03-01T23:33:01Z
dc.date.issued2013
dc.identifier.issn1475-6366
dc.identifier.urihttps://vinar.vin.bg.ac.rs/handle/123456789/5583
dc.description.abstractThis work has been focused on testing the influence of two selected Pt(II) complexes cisplatin, Pt(NH3)(2) Cl-2, and [Pt(dach)Cl-2] on the activity of porcine pancreatic phospholipase A(2) (PLA(2)). It has been assumed that this enzyme plays a role in carcinogenesis and that it could be a target in the tumour therapy. The results of this study show that both Pt(II) complexes inhibit the activity of the enzyme, though they bind to it in a different manner. While cisplatin interacts with the enzyme in an acompetitive manner, the stable interaction of [Pt(dach)Cl-2] with PLA(2) could not be detected under our experimental conditions.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172011/RS//
dc.rightsopenAccessen
dc.sourceJournal of Enzyme Inhibition and Medicinal Chemistryen
dc.subjectMALDI TOF MSen
dc.subjectmetallo-drugsen
dc.subjectphosphatidylcholineen
dc.titleInhibitory effect of cisplatin and [Pt(dach)Cl2] on the activity of phospholipase A2en
dc.typearticleen
dcterms.abstractПетковић Маријана; Радисављевиц, Маја; Камцева, Тина; Бугарциц, Зивадин Д.;
dc.citation.volume28
dc.citation.issue4
dc.citation.spage651
dc.citation.epage660
dc.identifier.wos000321693400001
dc.identifier.doi10.3109/14756366.2012.666539
dc.citation.rankM23
dc.identifier.pmid22424180
dc.identifier.scopus2-s2.0-84880057888
dc.identifier.fulltexthttps://vinar.vin.bg.ac.rs/bitstream/id/6329/bitstream_6329.pdf


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