Changes in Hypothalamus-Pituitary-Adrenal Axis Following Transient Ischemic Attack
Само за регистроване кориснике
2014
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Acute brain ischemia caused by transient ischemic attack initiates a complex sequence of events in the central nervous system and hypothalamic-pituitary-adrenal (HPA) axis which may ultimately culminate in neuronal and cell damage. The brain is highly susceptible to ischemia and in response to stress shows changes in morphology and chemistry that are largely reversible. These responses are known to modify the function of the HPA axis, but their mechanisms are not yet clear. Duration and size of the HPA axis activation are regulated by corticotropin-releasing hormone, vasopressin (AVP), and glucocorticoids, including cortisol. Numerous studies suggest that activation of these hormones following brain ischemia can result in neurohormonal dysfunction that can exacerbate long-term prognosis following stroke. These studies represent evidence that changes in the HPA axis play an important role in brain ischemia.
Кључне речи:
hypothalamic-pituitary-adrenal axis / acute brain ischemia / transient ischemic attack / strokeИзвор:
Angiology, 2014, 65, 8, 723-732Финансирање / пројекти:
- Каротидна болест у Србији - патолошка динамика, превенција, дијагностика и иновативни терапијски поступци (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41002)
- Хормонска регулација експресије и активности азот оксид синтазе и натријум-калијумове пумпе у експерименталним моделима инсулинске резистенције, дијабетеса и кардиоваскуларних поремећаја (RS-MESTD-Basic Research (BR or ON)-173033)
DOI: 10.1177/0003319713503487
ISSN: 0003-3197; 1940-1574
PubMed: 24065626
WoS: 000340715700011
Scopus: 2-s2.0-84905898967
Колекције
Институција/група
VinčaTY - JOUR AU - Radak, Đorđe J. AU - Resanović, Ivana AU - Isenović, Esma R. PY - 2014 UR - https://vinar.vin.bg.ac.rs/handle/123456789/54 AB - Acute brain ischemia caused by transient ischemic attack initiates a complex sequence of events in the central nervous system and hypothalamic-pituitary-adrenal (HPA) axis which may ultimately culminate in neuronal and cell damage. The brain is highly susceptible to ischemia and in response to stress shows changes in morphology and chemistry that are largely reversible. These responses are known to modify the function of the HPA axis, but their mechanisms are not yet clear. Duration and size of the HPA axis activation are regulated by corticotropin-releasing hormone, vasopressin (AVP), and glucocorticoids, including cortisol. Numerous studies suggest that activation of these hormones following brain ischemia can result in neurohormonal dysfunction that can exacerbate long-term prognosis following stroke. These studies represent evidence that changes in the HPA axis play an important role in brain ischemia. T2 - Angiology T1 - Changes in Hypothalamus-Pituitary-Adrenal Axis Following Transient Ischemic Attack VL - 65 IS - 8 SP - 723 EP - 732 DO - 10.1177/0003319713503487 ER -
@article{ author = "Radak, Đorđe J. and Resanović, Ivana and Isenović, Esma R.", year = "2014", abstract = "Acute brain ischemia caused by transient ischemic attack initiates a complex sequence of events in the central nervous system and hypothalamic-pituitary-adrenal (HPA) axis which may ultimately culminate in neuronal and cell damage. The brain is highly susceptible to ischemia and in response to stress shows changes in morphology and chemistry that are largely reversible. These responses are known to modify the function of the HPA axis, but their mechanisms are not yet clear. Duration and size of the HPA axis activation are regulated by corticotropin-releasing hormone, vasopressin (AVP), and glucocorticoids, including cortisol. Numerous studies suggest that activation of these hormones following brain ischemia can result in neurohormonal dysfunction that can exacerbate long-term prognosis following stroke. These studies represent evidence that changes in the HPA axis play an important role in brain ischemia.", journal = "Angiology", title = "Changes in Hypothalamus-Pituitary-Adrenal Axis Following Transient Ischemic Attack", volume = "65", number = "8", pages = "723-732", doi = "10.1177/0003319713503487" }
Radak, Đ. J., Resanović, I.,& Isenović, E. R.. (2014). Changes in Hypothalamus-Pituitary-Adrenal Axis Following Transient Ischemic Attack. in Angiology, 65(8), 723-732. https://doi.org/10.1177/0003319713503487
Radak ĐJ, Resanović I, Isenović ER. Changes in Hypothalamus-Pituitary-Adrenal Axis Following Transient Ischemic Attack. in Angiology. 2014;65(8):723-732. doi:10.1177/0003319713503487 .
Radak, Đorđe J., Resanović, Ivana, Isenović, Esma R., "Changes in Hypothalamus-Pituitary-Adrenal Axis Following Transient Ischemic Attack" in Angiology, 65, no. 8 (2014):723-732, https://doi.org/10.1177/0003319713503487 . .