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Pore Geometry of Ceramic Device: the Key Factor of Drug Release Kinetics
dc.creator | Čolović, Božana M. | |
dc.creator | Milivojević, Dušan | |
dc.creator | Babić-Stojić, Branka S. | |
dc.creator | Jokanović, Vukoman R. | |
dc.date.accessioned | 2018-03-01T23:23:26Z | |
dc.date.available | 2018-03-01T23:23:26Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 0350-820X | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/5473 | |
dc.description.abstract | Release kinetics of tigecycline, a potential antibiotic in treatment of osteomyelitis, from calcium hydroxyapatite (CHA), as one of the most important ceramic materials in bone tissue engineering, was investigated in this study. Tigecycline, in solid state, was mixed with CHA powder and the obtained mixture was compressed into tablets using two different pressures. These tablets were immersed in a phosphate-buffered saline solution and tigecycline release was measured by a UV-VIS spectrophotometer. The total release time was 5 or 28 days, depending on the pressure applied during compression. It was shown that there is a close relationship between pore sizes and drug release rate. The drug release kinetics was interpreted on the base of pore sizes and pore size distribution. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172026/RS// | |
dc.rights | openAccess | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Science of Sintering | en |
dc.subject | Hydroxyapatite | en |
dc.subject | Pore geometry | en |
dc.subject | Drug release | en |
dc.title | Pore Geometry of Ceramic Device: the Key Factor of Drug Release Kinetics | en |
dc.type | article | en |
dc.rights.license | BY | |
dcterms.abstract | Јокановић Вукоман Р.; Чоловић Божана; Миливојевић Душан; Бабић-Стојић Бранка С.; | |
dc.citation.volume | 45 | |
dc.citation.issue | 1 | |
dc.citation.spage | 107 | |
dc.citation.epage | 116 | |
dc.identifier.wos | 000318150200011 | |
dc.identifier.doi | 10.2298/SOS1301107C | |
dc.citation.rank | M23 | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-84877711467 | |
dc.identifier.fulltext | https://vinar.vin.bg.ac.rs//bitstream/id/13406/5469.pdf |
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030 - Laboratorija za radijacionu hemiju i fiziku
Department of Radiation Chemistry and Physics