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dc.creatorStanojlović, Miloš R.
dc.creatorHorvat, Anica
dc.creatorGuševac, Ivana
dc.creatorGrković, Ivana
dc.creatorMitrović, Nataša Lj.
dc.creatorBuzadzic, I.
dc.creatorDrakulić, Dunja R.
dc.date.accessioned2018-03-01T23:21:02Z
dc.date.available2018-03-01T23:21:02Z
dc.date.issued2014
dc.identifier.issn0015-5500
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/5445
dc.description.abstractTo study time-dependent and gender-specific intracellular and biochemical mechanisms that lead to neurodegeneration due to moderate but persistent reduction of cerebral blood flow, adult male and female Wistar rats were divided into two main groups controls that underwent sham operation and animals subjected to permanent bilateral occlusion of common carotid arteries. Animals were sacrificed 3, 7 or 90 days following the insult. Expression of several apoptotic proteins in synaptic fractions along with Fluoro-Jade B staining and DNA fragmentation assay were used to estimate the apoptotic processes and potential neurodegeneration in cerebral cortex. Data suggest a time-specific increase of Bax as well as time- and gender-associated down-regulation in protein expression of Bcl-2, up-regulation of procaspase 3, accompanied with increased cleavage of procaspase 3 and PARP in synaptic terminals. Furthermore, time- but not gender-specific neurodegeneration was observed. Our findings support the concept of time- and gender-associated response to permanent bilateral occlusion of common carotid arteries, which would enable better understanding of the mechanisms underlying cerebral hypoperfusion.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173044/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41014/RS//
dc.rightsrestrictedAccessen
dc.sourceFolia Biologicaen
dc.subjectneurodegenerationen
dc.subjectapoptosisen
dc.subjectcerebral hypoperfusionen
dc.subjectcerebral cortexen
dc.subjectraten
dc.titleTime Course of Cerebral Hypoperfusion-Induced Neurodegenerative Changes in the Cortex of Male and Female Ratsen
dc.typearticleen
dcterms.abstractГрковић Ивана; Хорват, Aница; Митровић Натаса; Бузадзиц, И.; Гусевац, И.; Станојловиц, М.; Дракулић Дуња;
dc.citation.volume60
dc.citation.issue3
dc.citation.spage123
dc.citation.epage132
dc.identifier.wos000338479400004
dc.citation.rankM23
dc.identifier.pmid25056435


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