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dc.creatorFilipovic, Branko
dc.creatorSosic-Jurjevic, Branka
dc.creatorAjdzanovic, Vladimir
dc.creatorZivanovic, Jasmina
dc.creatorIsenović, Esma R.
dc.creatorPopovska-Percinic, Florina
dc.creatorMilosevic, Verica
dc.date.accessioned2018-03-01T16:07:08Z
dc.date.available2018-03-01T16:07:08Z
dc.date.issued2015
dc.identifier.issn0021-8782 (print)
dc.identifier.issn1469-7580 (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/535
dc.description.abstractThyroid C-cells produce calcitonin (CT), a hypocalcemic hormone, that acts as an inhibitor of bone resorption. In this study, we investigated the effects of tamoxifen (TAM) as a selective estrogen receptor modulator on thyroid C-cells, trabecular bone and biochemical markers of bone metabolism in an animal model of androgen deficiency, represented by middle-aged orchidectomized (Orx) rats. Fifteen-month-old male Wistar rats were divided into: Orx and sham-operated (SO) groups. Rats from one Orx group were injected subcutaneously with TAM citrate (Orx + TAM; 0.3 mgkg(-1) b.w.), while the rats from SO and a second Orx group received vehicle alone, once a day for 3 weeks. The peroxidase-antiperoxidase method was applied for localization of CT in C-cells. Thyroid C-cells were morphometrically and ultrastructurally analyzed. An ImageJ image-processing program was used to measure bone histomorphometric parameters. Blood serum samples were analyzed for CT, osteocalcin (OC), calcium (Ca2+) and phosphorus (P). Urinary Ca2+ concentrations were measured. TAM treatment significantly increased thyroid C-cell volume (V-c) and serum CT when compared with vehicle-treated Orx rats. Analysis of trabecular microarchitecture of the tibia showed that administration of TAM significantly increased cancellous bone area, trabecular thickness and trabecular number, whereas trabecular separation was significantly decreased compared with vehicle-treated Orx rats. Serum OC and urinary Ca2+ concentrations were significantly lower in comparison with the control Orx group. These results indicate that in our rat model of androgen deficiency, TAM stimulated calcitonin-producing thyroid C-cells and increased trabecular bone mass.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173009/RS//
dc.rightsopenAccessen
dc.sourceJournal of Anatomyen
dc.subjectandrogen deficiencyen
dc.subjectboneen
dc.subjectcalcitoninen
dc.subjectratsen
dc.subjecttamoxifenen
dc.subjectthyroid C-cellsen
dc.titleTamoxifen stimulates calcitonin-producing thyroid C-cells and prevents trabecular bone loss in a rat model of androgen deficiencyen
dc.typearticleen
dcterms.abstractСосиц-Јурјевиц, Бранка; Исеновић Есма; Филиповиц, Бранко; Aјдзановиц, Владимир; Милосевиц, Верица; Зивановиц, Јасмина; Поповска-Перциниц, Флорина;
dc.citation.volume226
dc.citation.issue5
dc.citation.spage489
dc.citation.epage496
dc.identifier.wos000354533300009
dc.identifier.doi10.1111/joa.12298
dc.citation.rankM21
dc.identifier.pmid25851663
dc.identifier.scopus2-s2.0-84929288927
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs//bitstream/id/4838/joa12298.pdf


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