Significant increase in anxiety during aging in mGlu5 receptor knockout mice
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Inta, DragosVogt, M. A.
Luoni, A.
Filipović, Dragana
Lima-Ojeda, J. M.
Pfeiffer, N.
Gasparini, F.
Riva, M. A.
Gass, Peter
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Glutamatergic mechanisms regulate neuronal circuits implicated in mood and anxiety. Emotional disorders as anxiety and depression are particularly difficult to treat during aging and mechanisms underlying emotional disturbances in the brain of the elderly are poorly understood. This may result from the small number of studies investigating these disorders in aged animals. Among glutamate receptors, metabotropic mGlu5 receptors are thought to play an important role, since their pharmacological blockade induces strong anxiolytic effects. However, the implication of mGlu5 in regulating anxiety is not yet completely understood. Here we analyzed both young adult and aged mice lacking mGlu5 receptors, to clarify, if genetic deletion of the receptor induces similar to pharmacological blockade anxiolytic effects. Unexpectedly, mGlu5 receptor knockout (KO) mice showed increased anxiety accentuating with aging. In contrast, young adult mice displayed an anti-depressive-like phenotype that was no... longer detectable in aged animals. Our data support important distinct roles of mGlu5 receptors in modulating anxiety and depression during aging. (C) 2012 Elsevier B.V. All rights reserved.
Keywords:
mGlu5 / Anxiety / Deletion / Depression / Genetic / AgingSource:
Behavioural Brain Research, 2013, 241, 27-31Funding / projects:
- Deutsche Forschungsgemeinschaft [GA427/11-1], DAAD, BASILEUS fellowship, DAAD-CONACYT fellowship
DOI: 10.1016/j.bbr.2012.11.042
ISSN: 0166-4328
PubMed: 23228523
WoS: 000315308700004
Scopus: 2-s2.0-84871833960
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VinčaTY - JOUR AU - Inta, Dragos AU - Vogt, M. A. AU - Luoni, A. AU - Filipović, Dragana AU - Lima-Ojeda, J. M. AU - Pfeiffer, N. AU - Gasparini, F. AU - Riva, M. A. AU - Gass, Peter PY - 2013 UR - https://vinar.vin.bg.ac.rs/handle/123456789/5328 AB - Glutamatergic mechanisms regulate neuronal circuits implicated in mood and anxiety. Emotional disorders as anxiety and depression are particularly difficult to treat during aging and mechanisms underlying emotional disturbances in the brain of the elderly are poorly understood. This may result from the small number of studies investigating these disorders in aged animals. Among glutamate receptors, metabotropic mGlu5 receptors are thought to play an important role, since their pharmacological blockade induces strong anxiolytic effects. However, the implication of mGlu5 in regulating anxiety is not yet completely understood. Here we analyzed both young adult and aged mice lacking mGlu5 receptors, to clarify, if genetic deletion of the receptor induces similar to pharmacological blockade anxiolytic effects. Unexpectedly, mGlu5 receptor knockout (KO) mice showed increased anxiety accentuating with aging. In contrast, young adult mice displayed an anti-depressive-like phenotype that was no longer detectable in aged animals. Our data support important distinct roles of mGlu5 receptors in modulating anxiety and depression during aging. (C) 2012 Elsevier B.V. All rights reserved. T2 - Behavioural Brain Research T1 - Significant increase in anxiety during aging in mGlu5 receptor knockout mice VL - 241 SP - 27 EP - 31 DO - 10.1016/j.bbr.2012.11.042 ER -
@article{ author = "Inta, Dragos and Vogt, M. A. and Luoni, A. and Filipović, Dragana and Lima-Ojeda, J. M. and Pfeiffer, N. and Gasparini, F. and Riva, M. A. and Gass, Peter", year = "2013", abstract = "Glutamatergic mechanisms regulate neuronal circuits implicated in mood and anxiety. Emotional disorders as anxiety and depression are particularly difficult to treat during aging and mechanisms underlying emotional disturbances in the brain of the elderly are poorly understood. This may result from the small number of studies investigating these disorders in aged animals. Among glutamate receptors, metabotropic mGlu5 receptors are thought to play an important role, since their pharmacological blockade induces strong anxiolytic effects. However, the implication of mGlu5 in regulating anxiety is not yet completely understood. Here we analyzed both young adult and aged mice lacking mGlu5 receptors, to clarify, if genetic deletion of the receptor induces similar to pharmacological blockade anxiolytic effects. Unexpectedly, mGlu5 receptor knockout (KO) mice showed increased anxiety accentuating with aging. In contrast, young adult mice displayed an anti-depressive-like phenotype that was no longer detectable in aged animals. Our data support important distinct roles of mGlu5 receptors in modulating anxiety and depression during aging. (C) 2012 Elsevier B.V. All rights reserved.", journal = "Behavioural Brain Research", title = "Significant increase in anxiety during aging in mGlu5 receptor knockout mice", volume = "241", pages = "27-31", doi = "10.1016/j.bbr.2012.11.042" }
Inta, D., Vogt, M. A., Luoni, A., Filipović, D., Lima-Ojeda, J. M., Pfeiffer, N., Gasparini, F., Riva, M. A.,& Gass, P.. (2013). Significant increase in anxiety during aging in mGlu5 receptor knockout mice. in Behavioural Brain Research, 241, 27-31. https://doi.org/10.1016/j.bbr.2012.11.042
Inta D, Vogt MA, Luoni A, Filipović D, Lima-Ojeda JM, Pfeiffer N, Gasparini F, Riva MA, Gass P. Significant increase in anxiety during aging in mGlu5 receptor knockout mice. in Behavioural Brain Research. 2013;241:27-31. doi:10.1016/j.bbr.2012.11.042 .
Inta, Dragos, Vogt, M. A., Luoni, A., Filipović, Dragana, Lima-Ojeda, J. M., Pfeiffer, N., Gasparini, F., Riva, M. A., Gass, Peter, "Significant increase in anxiety during aging in mGlu5 receptor knockout mice" in Behavioural Brain Research, 241 (2013):27-31, https://doi.org/10.1016/j.bbr.2012.11.042 . .