The role of G protein coupled receptor kinases in neurocardiovascular pathophysiology
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In coronary artery disease the G protein related kinases (GRKs) play a role in desensitization of beta-adrenoreceptors (AR) after coronary occlusion. Targeted deletion and lowering of cardiac myocyte GRK-2 decreases the risk of post-ischemic heart failure (HF). Studies carried out in humans confirm the role of GRK-2 as a marker for the progression of HF after myocardial infarction (MI). The level of GRK-2 could be an indicator of beta-AR blocker efficacy in patients with acute coronary syndrome. Elevated levels of GRK-2 are an early ubiquitous consequence of myocardial injury. In hypertension an increased level of GRK-2 was reported in both animal models and human studies. The role of GRKs in vagally mediated disorders such as vasovagal syncope and atrial fibrillation remains controversial. The role of GRKs in the pathogenesis of neurocardiological diseases provides an insight into the molecular pathogenesis process, opens potential therapeutic options and suggests new directions for s...cientific research.
Кључне речи:
autonomic / sympathetic / vagal / molecular signaling pathwayИзвор:
Archives of Medical Science, 2012, 8, 6, 970-977Финансирање / пројекти:
- Хормонска регулација експресије и активности азот оксид синтазе и натријум-калијумове пумпе у експерименталним моделима инсулинске резистенције, дијабетеса и кардиоваскуларних поремећаја (RS-MESTD-Basic Research (BR or ON)-173033)
- Интегрална студија идентификације регионалних генетских фактора ризика и фактора ризика животне средине за масовне незаразне болести хумане популације у Србији - INGEMA_S (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41028)
DOI: 10.5114/aoms.2012.32466
ISSN: 1734-1922
PubMed: 23319968
WoS: 000312926600004
Scopus: 2-s2.0-84873168698
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Институција/група
VinčaTY - JOUR AU - Bojić, Tijana AU - Sudar, Emina AU - Mikhailidis, Dimitri P. AU - Alavantić, Dragan AU - Isenović, Esma R. PY - 2012 UR - https://vinar.vin.bg.ac.rs/handle/123456789/5232 AB - In coronary artery disease the G protein related kinases (GRKs) play a role in desensitization of beta-adrenoreceptors (AR) after coronary occlusion. Targeted deletion and lowering of cardiac myocyte GRK-2 decreases the risk of post-ischemic heart failure (HF). Studies carried out in humans confirm the role of GRK-2 as a marker for the progression of HF after myocardial infarction (MI). The level of GRK-2 could be an indicator of beta-AR blocker efficacy in patients with acute coronary syndrome. Elevated levels of GRK-2 are an early ubiquitous consequence of myocardial injury. In hypertension an increased level of GRK-2 was reported in both animal models and human studies. The role of GRKs in vagally mediated disorders such as vasovagal syncope and atrial fibrillation remains controversial. The role of GRKs in the pathogenesis of neurocardiological diseases provides an insight into the molecular pathogenesis process, opens potential therapeutic options and suggests new directions for scientific research. T2 - Archives of Medical Science T1 - The role of G protein coupled receptor kinases in neurocardiovascular pathophysiology VL - 8 IS - 6 SP - 970 EP - 977 DO - 10.5114/aoms.2012.32466 ER -
@article{ author = "Bojić, Tijana and Sudar, Emina and Mikhailidis, Dimitri P. and Alavantić, Dragan and Isenović, Esma R.", year = "2012", abstract = "In coronary artery disease the G protein related kinases (GRKs) play a role in desensitization of beta-adrenoreceptors (AR) after coronary occlusion. Targeted deletion and lowering of cardiac myocyte GRK-2 decreases the risk of post-ischemic heart failure (HF). Studies carried out in humans confirm the role of GRK-2 as a marker for the progression of HF after myocardial infarction (MI). The level of GRK-2 could be an indicator of beta-AR blocker efficacy in patients with acute coronary syndrome. Elevated levels of GRK-2 are an early ubiquitous consequence of myocardial injury. In hypertension an increased level of GRK-2 was reported in both animal models and human studies. The role of GRKs in vagally mediated disorders such as vasovagal syncope and atrial fibrillation remains controversial. The role of GRKs in the pathogenesis of neurocardiological diseases provides an insight into the molecular pathogenesis process, opens potential therapeutic options and suggests new directions for scientific research.", journal = "Archives of Medical Science", title = "The role of G protein coupled receptor kinases in neurocardiovascular pathophysiology", volume = "8", number = "6", pages = "970-977", doi = "10.5114/aoms.2012.32466" }
Bojić, T., Sudar, E., Mikhailidis, D. P., Alavantić, D.,& Isenović, E. R.. (2012). The role of G protein coupled receptor kinases in neurocardiovascular pathophysiology. in Archives of Medical Science, 8(6), 970-977. https://doi.org/10.5114/aoms.2012.32466
Bojić T, Sudar E, Mikhailidis DP, Alavantić D, Isenović ER. The role of G protein coupled receptor kinases in neurocardiovascular pathophysiology. in Archives of Medical Science. 2012;8(6):970-977. doi:10.5114/aoms.2012.32466 .
Bojić, Tijana, Sudar, Emina, Mikhailidis, Dimitri P., Alavantić, Dragan, Isenović, Esma R., "The role of G protein coupled receptor kinases in neurocardiovascular pathophysiology" in Archives of Medical Science, 8, no. 6 (2012):970-977, https://doi.org/10.5114/aoms.2012.32466 . .