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dc.creatorMladenovic, D.
dc.creatorHrncic, D.
dc.creatorRasic-Markovic, A.
dc.creatorPuškaš, Nela
dc.creatorPetrović, Srđan M.
dc.creatorStanojlovic, O.
dc.date.accessioned2018-03-01T23:02:14Z
dc.date.available2018-03-01T23:02:14Z
dc.date.issued2013
dc.identifier.issn0960-3271 (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/5226
dc.description.abstractThioacetamide (TAA) is widely used as a model of hepatic encephalopathy (HE). The aim of our study was to investigate the effects of TAA on electroencephalographic (EEG) changes in rats and to compare them with human HE. Male Wistar rats were divided into groups: (1) saline-treated group and (2) TAA-treated groups: TAA(300) (300 mg/kg), TAA(600) (600 mg/kg), and TAA(900) (900 mg/kg). Daily dose of TAA (300 mg/kg) was administered intraperitoneally once (TAA(300)), twice (TAA(600)), or thrice (TAA(900)) in subsequent days. EEG changes were recorded about 24 h after the last dose of TAA. Absolute and relative power density in alpha bands were significantly higher in TAA(300) versus control group. In TAA(300), absolute beta power density was higher and relative beta power density was lower versus control group. Absolute alpha, theta, delta, and relative theta power were significantly lower, while relative power in delta band was significantly higher in TAA(900) versus control group (p LT 0.01). In conclusion, decrease in EEG voltage with an increase in delta relative power, which correspond to the EEG manifestations of severe HE in humans, was observed in TAA(900) group. Electrical activity in TAA(300) group correlates with mild HE in humans.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175032/RS//
dc.rightsrestrictedAccessen
dc.sourceHuman and Experimental Toxicologyen
dc.subjectThioacetamideen
dc.subjecthepatic encephalopathyen
dc.subjectEEGen
dc.subjectspectral analysisen
dc.subjectratsen
dc.titleSpectral analysis of thioacetamide-induced electroencephalographic changes in ratsen
dc.typearticleen
dcterms.abstractПускас, Н.; Расиц-Марковиц, A.; Хрнциц, Д.; Младеновиц, Д.; Станојловиц, О.; Петровицх, С.;
dc.citation.volume32
dc.citation.issue1
dc.citation.spage90
dc.citation.epage100
dc.identifier.wos000312692600010
dc.identifier.doi10.1177/0960327112456312
dc.citation.rankM23
dc.identifier.pmid23111881
dc.identifier.scopus2-s2.0-84871595687


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