Thioacetamide (TAA) is widely used as a model of hepatic encephalopathy (HE). The aim of our study was to investigate the effects of TAA on electroencephalographic (EEG) changes in rats and to compare them with human HE. Male Wistar rats were divided into groups: (1) saline-treated group and (2) TAA-treated groups: TAA(300) (300 mg/kg), TAA(600) (600 mg/kg), and TAA(900) (900 mg/kg). Daily dose of TAA (300 mg/kg) was administered intraperitoneally once (TAA(300)), twice (TAA(600)), or thrice (TAA(900)) in subsequent days. EEG changes were recorded about 24 h after the last dose of TAA. Absolute and relative power density in alpha bands were significantly higher in TAA(300) versus control group. In TAA(300), absolute beta power density was higher and relative beta power density was lower versus control group. Absolute alpha, theta, delta, and relative theta power were significantly lower, while relative power in delta band was significantly higher in TAA(900) versus control group (p LT ...0.01). In conclusion, decrease in EEG voltage with an increase in delta relative power, which correspond to the EEG manifestations of severe HE in humans, was observed in TAA(900) group. Electrical activity in TAA(300) group correlates with mild HE in humans.
TY - JOUR
AU - Mladenovic, D.
AU - Hrnčić, Dragan
AU - Rašić-Marković, Aleksandra
AU - Puškaš, Nela
AU - Petrovic, S.
AU - Stanojlović, Olivera
PY - 2013
UR - https://vinar.vin.bg.ac.rs/handle/123456789/5226
AB - Thioacetamide (TAA) is widely used as a model of hepatic encephalopathy (HE). The aim of our study was to investigate the effects of TAA on electroencephalographic (EEG) changes in rats and to compare them with human HE. Male Wistar rats were divided into groups: (1) saline-treated group and (2) TAA-treated groups: TAA(300) (300 mg/kg), TAA(600) (600 mg/kg), and TAA(900) (900 mg/kg). Daily dose of TAA (300 mg/kg) was administered intraperitoneally once (TAA(300)), twice (TAA(600)), or thrice (TAA(900)) in subsequent days. EEG changes were recorded about 24 h after the last dose of TAA. Absolute and relative power density in alpha bands were significantly higher in TAA(300) versus control group. In TAA(300), absolute beta power density was higher and relative beta power density was lower versus control group. Absolute alpha, theta, delta, and relative theta power were significantly lower, while relative power in delta band was significantly higher in TAA(900) versus control group (p LT 0.01). In conclusion, decrease in EEG voltage with an increase in delta relative power, which correspond to the EEG manifestations of severe HE in humans, was observed in TAA(900) group. Electrical activity in TAA(300) group correlates with mild HE in humans.
T2 - Human and Experimental Toxicology
T1 - Spectral analysis of thioacetamide-induced electroencephalographic changes in rats
VL - 32
IS - 1
SP - 90
EP - 100
DO - 10.1177/0960327112456312
ER -
@article{
author = "Mladenovic, D. and Hrnčić, Dragan and Rašić-Marković, Aleksandra and Puškaš, Nela and Petrovic, S. and Stanojlović, Olivera",
year = "2013",
abstract = "Thioacetamide (TAA) is widely used as a model of hepatic encephalopathy (HE). The aim of our study was to investigate the effects of TAA on electroencephalographic (EEG) changes in rats and to compare them with human HE. Male Wistar rats were divided into groups: (1) saline-treated group and (2) TAA-treated groups: TAA(300) (300 mg/kg), TAA(600) (600 mg/kg), and TAA(900) (900 mg/kg). Daily dose of TAA (300 mg/kg) was administered intraperitoneally once (TAA(300)), twice (TAA(600)), or thrice (TAA(900)) in subsequent days. EEG changes were recorded about 24 h after the last dose of TAA. Absolute and relative power density in alpha bands were significantly higher in TAA(300) versus control group. In TAA(300), absolute beta power density was higher and relative beta power density was lower versus control group. Absolute alpha, theta, delta, and relative theta power were significantly lower, while relative power in delta band was significantly higher in TAA(900) versus control group (p LT 0.01). In conclusion, decrease in EEG voltage with an increase in delta relative power, which correspond to the EEG manifestations of severe HE in humans, was observed in TAA(900) group. Electrical activity in TAA(300) group correlates with mild HE in humans.",
journal = "Human and Experimental Toxicology",
title = "Spectral analysis of thioacetamide-induced electroencephalographic changes in rats",
volume = "32",
number = "1",
pages = "90-100",
doi = "10.1177/0960327112456312"
}
Mladenovic, D., Hrnčić, D., Rašić-Marković, A., Puškaš, N., Petrovic, S.,& Stanojlović, O.. (2013). Spectral analysis of thioacetamide-induced electroencephalographic changes in rats. in Human and Experimental Toxicology, 32(1), 90-100.
https://doi.org/10.1177/0960327112456312
Mladenovic D, Hrnčić D, Rašić-Marković A, Puškaš N, Petrovic S, Stanojlović O. Spectral analysis of thioacetamide-induced electroencephalographic changes in rats. in Human and Experimental Toxicology. 2013;32(1):90-100.
doi:10.1177/0960327112456312 .
Mladenovic, D., Hrnčić, Dragan, Rašić-Marković, Aleksandra, Puškaš, Nela, Petrovic, S., Stanojlović, Olivera, "Spectral analysis of thioacetamide-induced electroencephalographic changes in rats" in Human and Experimental Toxicology, 32, no. 1 (2013):90-100,
https://doi.org/10.1177/0960327112456312 . .
