Pulse perturbation technique for determination of piroxicam in pharmaceuticals using an oscillatory reaction system
2013
Аутори
Pejić, Nataša D.Sarap, Nataša
Maksimović, Jelena P.
Anić, Slobodan R.
Kolar-Anić, Ljiljana Z.
Чланак у часопису
Метаподаци
Приказ свих података о документуАпстракт
A simple and reliable novel kinetic method for the determination of piroxicam (PX) was proposed and validated. For quantitative determination of PX, the Bray-Liebhafsky (BL) oscillatory reaction was used in a stable non-equilibrium stationary state close to the bifurcation point. Under the optimized reaction conditions (T = 55.0A degrees C, [H2SO4](0) = 7.60x10(-2) mol L-1, [KIO3](0) = 5.90x10(-2) mol L-1, [H2O2](0) = 1.50x10(-1) mol L-1 and j (0) = 2.95x10(-2) min(-1)), the linear relationship between maximal potential shift Delta E (m) , and PX concentration was obtained in the concentration range 11.2-480.5 A mu g mL(-1) with a detection limit of 9.9 A mu g mL(-1). The method had a rather good sample throughput of 25 samples h(-1) with a precision RSD = 4.7% as well as recoveries RCV a parts per thousand currency sign 104.4%. Applicability of the proposed method to the direct determination of piroxicam in different pharmaceutical formulations (tablets, ampoules and gel) was demonstr...ated.
Кључне речи:
Piroxicam / Perturbation technique / Bray-Liebhafsky oscillatory reaction / Pharmaceutical preparationsИзвор:
Central European Journal of Chemistry, 2013, 11, 2, 180-188Финансирање / пројекти:
- Динамика нелинеарних физичкохемијских и биохемијских система са моделирањем и предвиђањем њихових понашања под неравнотежним условима (RS-172015)
- Нове технологије за мониторинг и заштиту животног окружења од штетних хемијских супстанци и радијационог оптерећења (RS-43009)
DOI: 10.2478/s11532-012-0146-7
ISSN: 1895-1066
WoS: 000311778700008
Scopus: 2-s2.0-84875741601
Колекције
Институција/група
VinčaTY - JOUR AU - Pejić, Nataša D. AU - Sarap, Nataša AU - Maksimović, Jelena P. AU - Anić, Slobodan R. AU - Kolar-Anić, Ljiljana Z. PY - 2013 UR - https://vinar.vin.bg.ac.rs/handle/123456789/5183 AB - A simple and reliable novel kinetic method for the determination of piroxicam (PX) was proposed and validated. For quantitative determination of PX, the Bray-Liebhafsky (BL) oscillatory reaction was used in a stable non-equilibrium stationary state close to the bifurcation point. Under the optimized reaction conditions (T = 55.0A degrees C, [H2SO4](0) = 7.60x10(-2) mol L-1, [KIO3](0) = 5.90x10(-2) mol L-1, [H2O2](0) = 1.50x10(-1) mol L-1 and j (0) = 2.95x10(-2) min(-1)), the linear relationship between maximal potential shift Delta E (m) , and PX concentration was obtained in the concentration range 11.2-480.5 A mu g mL(-1) with a detection limit of 9.9 A mu g mL(-1). The method had a rather good sample throughput of 25 samples h(-1) with a precision RSD = 4.7% as well as recoveries RCV a parts per thousand currency sign 104.4%. Applicability of the proposed method to the direct determination of piroxicam in different pharmaceutical formulations (tablets, ampoules and gel) was demonstrated. T2 - Central European Journal of Chemistry T1 - Pulse perturbation technique for determination of piroxicam in pharmaceuticals using an oscillatory reaction system VL - 11 IS - 2 SP - 180 EP - 188 DO - 10.2478/s11532-012-0146-7 ER -
@article{ author = "Pejić, Nataša D. and Sarap, Nataša and Maksimović, Jelena P. and Anić, Slobodan R. and Kolar-Anić, Ljiljana Z.", year = "2013", abstract = "A simple and reliable novel kinetic method for the determination of piroxicam (PX) was proposed and validated. For quantitative determination of PX, the Bray-Liebhafsky (BL) oscillatory reaction was used in a stable non-equilibrium stationary state close to the bifurcation point. Under the optimized reaction conditions (T = 55.0A degrees C, [H2SO4](0) = 7.60x10(-2) mol L-1, [KIO3](0) = 5.90x10(-2) mol L-1, [H2O2](0) = 1.50x10(-1) mol L-1 and j (0) = 2.95x10(-2) min(-1)), the linear relationship between maximal potential shift Delta E (m) , and PX concentration was obtained in the concentration range 11.2-480.5 A mu g mL(-1) with a detection limit of 9.9 A mu g mL(-1). The method had a rather good sample throughput of 25 samples h(-1) with a precision RSD = 4.7% as well as recoveries RCV a parts per thousand currency sign 104.4%. Applicability of the proposed method to the direct determination of piroxicam in different pharmaceutical formulations (tablets, ampoules and gel) was demonstrated.", journal = "Central European Journal of Chemistry", title = "Pulse perturbation technique for determination of piroxicam in pharmaceuticals using an oscillatory reaction system", volume = "11", number = "2", pages = "180-188", doi = "10.2478/s11532-012-0146-7" }
Pejić, N. D., Sarap, N., Maksimović, J. P., Anić, S. R.,& Kolar-Anić, L. Z.. (2013). Pulse perturbation technique for determination of piroxicam in pharmaceuticals using an oscillatory reaction system. in Central European Journal of Chemistry, 11(2), 180-188. https://doi.org/10.2478/s11532-012-0146-7
Pejić ND, Sarap N, Maksimović JP, Anić SR, Kolar-Anić LZ. Pulse perturbation technique for determination of piroxicam in pharmaceuticals using an oscillatory reaction system. in Central European Journal of Chemistry. 2013;11(2):180-188. doi:10.2478/s11532-012-0146-7 .
Pejić, Nataša D., Sarap, Nataša, Maksimović, Jelena P., Anić, Slobodan R., Kolar-Anić, Ljiljana Z., "Pulse perturbation technique for determination of piroxicam in pharmaceuticals using an oscillatory reaction system" in Central European Journal of Chemistry, 11, no. 2 (2013):180-188, https://doi.org/10.2478/s11532-012-0146-7 . .