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Effects of altered hepatic lipid metabolism on regulation of hepatic iNOS

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Authors
Stanimirović, Julijana
Obradović, Milan M.
Zafirović, Sonja
Resanović, Ivana
Bogdanović, Nikola
Gluvić, Zoran
Mousa, Shaker A.
Isenović, Esma R.
Review
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Abstract
An altered hepatic lipid metabolism involves multifactorial pathologies such as hepatic inflammation, insulin resistance and oxidative stress. Immunity has an essential role in the regulation of glucose and lipid metabolism in the liver. Inducible nitric oxide (NO) synthase (iNOS) has been proposed as an important factor that interplays between immunity and energy metabolism and also in the pathogenesis of obesity-linked insulin resistance. In the liver, locally produced NO plays a protective role during inflammation, and the balance of NO protective and cytotoxic effects is very important. This review is focused on understanding the molecular mechanisms of iNOS regulation in the state of altered hepatic lipid metabolism, which is critical for developing new strategies for treatment of hepatic disorders.
Keywords:
inducible nitric oxide synthase / inflammation / lipid / liver / metabolism / nitric oxide
Source:
Clinical Lipidology, 2015, 10, 2, 167-175
Projects:
  • Hormonal regulation of expression and activity of the nitric oxide synthase and sodium-potassium pump in experimental models of insulin resistance, diabetes and cardiovascular disorders (RS-173033)

DOI: 10.2217/CLP.15.8

ISSN: 1758-4299 (print); 1758-4302 (electronic)

WoS: 000353412100006

Scopus: 2-s2.0-84928576652
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URI
http://vinar.vin.bg.ac.rs/handle/123456789/511
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Vinča

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