Influence of hydroxyapatite pore geometry on tigecycline release kinetics
Apstrakt
Calcium hydroxyapatite (CHA), as one of the most important ceramic materials in bone tissue engineering, was used as a delivery system for tigecycline, a potential antibiotic in treatment of osteomyelitis. Tigecycline, in a solid state, was mixed with CHA powder and the obtained mixture was compressed into tablets. The release of tigecycline from these tablets in a pH 7.4 phosphate-buffered saline solution was measured by a UV-vis spectrophotometer at 37 degrees C. The total dose of tigecycline was released for 5 to 30 days, depending on the applied pressure and drug concentration. A new drug release mechanism that determines the relationship between pore sizes and drug release rate is proposed. It explains and quantifies the drug release kinetics based on pore sizes and pore size distribution. (c) 2012 Elsevier Ltd and Techna Group S.r.l. All rights reserved.
Ključne reči:
Pore geometry / Hydroxyapatite / Multilevel carrier / Drug releaseIzvor:
Ceramics International, 2012, 38, 8, 6181-6189Finansiranje / projekti:
- Hemijsko i strukturno dizajniranje nanomaterijala za primenu u medicini i inženjerstvu tkiva (RS-MESTD-Basic Research (BR or ON)-172026)
DOI: 10.1016/j.ceramint.2012.04.069
ISSN: 0272-8842
WoS: 000309645000014
Scopus: 2-s2.0-84865749473
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Čolović, Božana M. AU - Pašalić, Snežana AU - Jokanović, Vukoman R. PY - 2012 UR - https://vinar.vin.bg.ac.rs/handle/123456789/5086 AB - Calcium hydroxyapatite (CHA), as one of the most important ceramic materials in bone tissue engineering, was used as a delivery system for tigecycline, a potential antibiotic in treatment of osteomyelitis. Tigecycline, in a solid state, was mixed with CHA powder and the obtained mixture was compressed into tablets. The release of tigecycline from these tablets in a pH 7.4 phosphate-buffered saline solution was measured by a UV-vis spectrophotometer at 37 degrees C. The total dose of tigecycline was released for 5 to 30 days, depending on the applied pressure and drug concentration. A new drug release mechanism that determines the relationship between pore sizes and drug release rate is proposed. It explains and quantifies the drug release kinetics based on pore sizes and pore size distribution. (c) 2012 Elsevier Ltd and Techna Group S.r.l. All rights reserved. T2 - Ceramics International T1 - Influence of hydroxyapatite pore geometry on tigecycline release kinetics VL - 38 IS - 8 SP - 6181 EP - 6189 DO - 10.1016/j.ceramint.2012.04.069 ER -
@article{ author = "Čolović, Božana M. and Pašalić, Snežana and Jokanović, Vukoman R.", year = "2012", abstract = "Calcium hydroxyapatite (CHA), as one of the most important ceramic materials in bone tissue engineering, was used as a delivery system for tigecycline, a potential antibiotic in treatment of osteomyelitis. Tigecycline, in a solid state, was mixed with CHA powder and the obtained mixture was compressed into tablets. The release of tigecycline from these tablets in a pH 7.4 phosphate-buffered saline solution was measured by a UV-vis spectrophotometer at 37 degrees C. The total dose of tigecycline was released for 5 to 30 days, depending on the applied pressure and drug concentration. A new drug release mechanism that determines the relationship between pore sizes and drug release rate is proposed. It explains and quantifies the drug release kinetics based on pore sizes and pore size distribution. (c) 2012 Elsevier Ltd and Techna Group S.r.l. All rights reserved.", journal = "Ceramics International", title = "Influence of hydroxyapatite pore geometry on tigecycline release kinetics", volume = "38", number = "8", pages = "6181-6189", doi = "10.1016/j.ceramint.2012.04.069" }
Čolović, B. M., Pašalić, S.,& Jokanović, V. R.. (2012). Influence of hydroxyapatite pore geometry on tigecycline release kinetics. in Ceramics International, 38(8), 6181-6189. https://doi.org/10.1016/j.ceramint.2012.04.069
Čolović BM, Pašalić S, Jokanović VR. Influence of hydroxyapatite pore geometry on tigecycline release kinetics. in Ceramics International. 2012;38(8):6181-6189. doi:10.1016/j.ceramint.2012.04.069 .
Čolović, Božana M., Pašalić, Snežana, Jokanović, Vukoman R., "Influence of hydroxyapatite pore geometry on tigecycline release kinetics" in Ceramics International, 38, no. 8 (2012):6181-6189, https://doi.org/10.1016/j.ceramint.2012.04.069 . .