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dc.creatorMarković, Zoran M.
dc.creatorRistic, Biljana Z.
dc.creatorArsikin, Katarina M.
dc.creatorKlisic, Djordje G.
dc.creatorHarhaji-Trajković, Ljubica M.
dc.creatorTodorović-Marković, Biljana
dc.creatorKepić, Dejan P.
dc.creatorKravić-Stevović, Tamara K.
dc.creatorJovanović, Svetlana P.
dc.creatorMilenkovic, Marina M.
dc.creatorMilivojević, Dušan
dc.creatorBumbaširević, Vladimir Ž.
dc.creatorDramićanin, Miroslav
dc.creatorTrajković, Vladimir S.
dc.date.accessioned2018-03-01T22:44:59Z
dc.date.available2018-03-01T22:44:59Z
dc.date.issued2012
dc.identifier.issn0142-9612 (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/5025
dc.description.abstractThe excellent photoluminescent properties of graphene quantum dots (GQD) makes them suitable candidates for biomedical applications, but their cytotoxicity has not been extensively studied. Here we show that electrochemically produced GQD irradiated with blue light (470 nm, 1 W) generate reactive oxygen species, including singlet oxygen, and kill U251 human glioma cells by causing oxidative stress. The cell death induced by photoexcited GQD displayed morphological and/or biochemical characteristics of both apoptosis (phosphatidylserine externalization, caspase activation. DNA fragmentation) and autophagy (formation of autophagic vesicles, LC3-I/LC3-II conversion, degradation of autophagic target p62). Moreover, a genetic inactivation of autophagy-essential LOB protein partly abrogated the photodynamic cytotoxicity of GQD. These data indicate potential usefulness of GQD in photodynamic therapy, but also raise concerns about their possible toxicity. (C) 2012 Elsevier Ltd. All rights reserved.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41025/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172003/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173053/RS//
dc.rightsrestrictedAccessen
dc.sourceBiomaterialsen
dc.subjectCarbonen
dc.subjectNanoparticleen
dc.subjectPhotosensitisationen
dc.subjectCytotoxicityen
dc.subjectApoptosisen
dc.titleGraphene quantum dots as autophagy-inducing photodynamic agentsen
dc.typearticleen
dcterms.abstractКепић Дејан; Марковић Зоран; Хархаји-Трајковиц, Љубица М.; Тодоровић-Марковић Биљана; Трајковиц, Владимир С.; Бумбасиревиц, Владимир З.; Миленковиц, Марина М.; Јовановиц, Светлана П.; Кравиц-Стевовиц, Тамара К.; Клисиц, Дјордје Г.; Aрсикин, Катарина М.; Ристиц, Биљана З.; Миливојевић Душан; Драмићанин Мирослав;
dc.citation.volume33
dc.citation.issue29
dc.citation.spage7084
dc.citation.epage7092
dc.identifier.wos000308269600019
dc.identifier.doi10.1016/j.biomaterials.2012.06.060
dc.citation.rankM21a
dc.identifier.pmid22795854
dc.identifier.scopus2-s2.0-84864304699


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