Fullerenol C-60(OH)(24) nano particles (FNP) show various biological activities in different experimental models. We evaluated genotoxic and antigenotoxic effects of FNP on human peripheral blood lymphocytes (PBL) using two cytogenetic assays. The effects of FNP were evaluated on the frequency of chromosomal aberrations (CA) and micronuclei (MN) on undamaged and mitomycin C (MMC)-damaged PBL. FNP number distribution in a culture medium with serum showed that predominant particles were about 180 nm and 90 nm respectively. Cytogenetic assays showed that FNP decreased chromosomal aberrations and micronucleus frequency on the undamaged and the MMC- damaged human PBL at concentration range from 5.54 mu M to 221.60 mu M. Our research confirmed that FNP did not exhibit genotoxic but induced antigenotoxic effects at subcytotoxic concentrations on human lymphocytes.
TY - JOUR
AU - Mrđanović, Jasminka Ž.
AU - Solajic, Slavica V.
AU - Bogdanović, Višnja V.
AU - Đorđević, Aleksandar N.
AU - Bogdanović, Gordana M.
AU - Injac, Rade D.
AU - Rakočević, Zlatko Lj.
PY - 2012
UR - https://vinar.vin.bg.ac.rs/handle/123456789/4935
AB - Fullerenol C-60(OH)(24) nano particles (FNP) show various biological activities in different experimental models. We evaluated genotoxic and antigenotoxic effects of FNP on human peripheral blood lymphocytes (PBL) using two cytogenetic assays. The effects of FNP were evaluated on the frequency of chromosomal aberrations (CA) and micronuclei (MN) on undamaged and mitomycin C (MMC)-damaged PBL. FNP number distribution in a culture medium with serum showed that predominant particles were about 180 nm and 90 nm respectively. Cytogenetic assays showed that FNP decreased chromosomal aberrations and micronucleus frequency on the undamaged and the MMC- damaged human PBL at concentration range from 5.54 mu M to 221.60 mu M. Our research confirmed that FNP did not exhibit genotoxic but induced antigenotoxic effects at subcytotoxic concentrations on human lymphocytes.
T2 - Digest Journal of Nanomaterials and Biostructures
T1 - Effects of Fullerenol Nano Particles C-60(Oh)(24) on Micronuclei and Chromosomal Aberrations Frequency in Peripheral Blood Lymphocytes
VL - 7
IS - 2
SP - 673
EP - 686
UR - https://hdl.handle.net/21.15107/rcub_vinar_4935
ER -
@article{
author = "Mrđanović, Jasminka Ž. and Solajic, Slavica V. and Bogdanović, Višnja V. and Đorđević, Aleksandar N. and Bogdanović, Gordana M. and Injac, Rade D. and Rakočević, Zlatko Lj.",
year = "2012",
abstract = "Fullerenol C-60(OH)(24) nano particles (FNP) show various biological activities in different experimental models. We evaluated genotoxic and antigenotoxic effects of FNP on human peripheral blood lymphocytes (PBL) using two cytogenetic assays. The effects of FNP were evaluated on the frequency of chromosomal aberrations (CA) and micronuclei (MN) on undamaged and mitomycin C (MMC)-damaged PBL. FNP number distribution in a culture medium with serum showed that predominant particles were about 180 nm and 90 nm respectively. Cytogenetic assays showed that FNP decreased chromosomal aberrations and micronucleus frequency on the undamaged and the MMC- damaged human PBL at concentration range from 5.54 mu M to 221.60 mu M. Our research confirmed that FNP did not exhibit genotoxic but induced antigenotoxic effects at subcytotoxic concentrations on human lymphocytes.",
journal = "Digest Journal of Nanomaterials and Biostructures",
title = "Effects of Fullerenol Nano Particles C-60(Oh)(24) on Micronuclei and Chromosomal Aberrations Frequency in Peripheral Blood Lymphocytes",
volume = "7",
number = "2",
pages = "673-686",
url = "https://hdl.handle.net/21.15107/rcub_vinar_4935"
}
Mrđanović, J. Ž., Solajic, S. V., Bogdanović, V. V., Đorđević, A. N., Bogdanović, G. M., Injac, R. D.,& Rakočević, Z. Lj.. (2012). Effects of Fullerenol Nano Particles C-60(Oh)(24) on Micronuclei and Chromosomal Aberrations Frequency in Peripheral Blood Lymphocytes. in Digest Journal of Nanomaterials and Biostructures, 7(2), 673-686.
https://hdl.handle.net/21.15107/rcub_vinar_4935
Mrđanović JŽ, Solajic SV, Bogdanović VV, Đorđević AN, Bogdanović GM, Injac RD, Rakočević ZL. Effects of Fullerenol Nano Particles C-60(Oh)(24) on Micronuclei and Chromosomal Aberrations Frequency in Peripheral Blood Lymphocytes. in Digest Journal of Nanomaterials and Biostructures. 2012;7(2):673-686.
https://hdl.handle.net/21.15107/rcub_vinar_4935 .
Mrđanović, Jasminka Ž., Solajic, Slavica V., Bogdanović, Višnja V., Đorđević, Aleksandar N., Bogdanović, Gordana M., Injac, Rade D., Rakočević, Zlatko Lj., "Effects of Fullerenol Nano Particles C-60(Oh)(24) on Micronuclei and Chromosomal Aberrations Frequency in Peripheral Blood Lymphocytes" in Digest Journal of Nanomaterials and Biostructures, 7, no. 2 (2012):673-686,
https://hdl.handle.net/21.15107/rcub_vinar_4935 .
