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dc.creatorGodevac, Dejan
dc.creatorTešević, Vele V.
dc.creatorVajs, Vlatka
dc.creatorMilosavljević, Slobodan
dc.creatorZdunic, Gordana
dc.creatorOrdevic, Boban
dc.creatorStanković, Miroslava
dc.date.accessioned2018-03-01T22:36:16Z
dc.date.available2018-03-01T22:36:16Z
dc.date.issued2012
dc.identifier.issn0022-1147
dc.identifier.urihttps://vinar.vin.bg.ac.rs/handle/123456789/4923
dc.description.abstractOn the basis of LC/UV/MS analysis, 35 compounds from the extracts of seeds of black, red, and white currants (2 cultivars of each) were identified. Black currants cultivars contained protocatechuic acid and p-hydroxybenzoic acid, and traces of nitril containing phenolic acids. The presence of synapoyl glucoside was characteristic for cv. Malling Jewel. Sesquiterpenoid glycosides and carboxymethylindol glycosides were present mainly in white and red currant cultivars. Blackcurrant seeds contained higher amounts of flavonoids, especially rutin, isoquercetin, and taxifolin. The currant seed extracts were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The frequency of MN was scored in binucleated cells, and the cultivars of black currants showed the best antioxidant potential. At a concentration of only 0.17 mg/mL, extract of the seed cv. Malling Jewel effected a decrease in the frequency of MN of 60% compared with control cell cultures. Practical Application: Our results provide evidence of protective effects of currant seed extracts and isolated pure compounds on cytogenetic damages in human lymphocytes. Thus, currant seed extracts could exert beneficial effects in quite a few diseases, for many of the biological actions have been attributed to their antioxidant properties.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS//
dc.rightsrestrictedAccessen
dc.sourceJournal of Food Scienceen
dc.subjectcarboxymethylindol glycosidesen
dc.subjectcurrantsen
dc.subjectdihydrophaseic acid glycosidesen
dc.subjectmicronucleusen
dc.subjectpolyphenolicsen
dc.titleChemical Composition of Currant Seed Extracts and Their Protective Effect on Human Lymphocytes DNAen
dc.typearticleen
dcterms.abstractСтанковиц, Мирослава; Ордевиц, Бобан; Здуниц, Гордана; Милосављевиц, Слободан; Тесевиц, Веле; Вајс, Влатка; Годевац, Дејан;
dc.citation.volume77
dc.citation.issue7
dc.citation.spageC779
dc.citation.epageC783
dc.identifier.wos000305975700030
dc.identifier.doi10.1111/j.1750-3841.2012.02756.x
dc.citation.rankM22
dc.identifier.pmid22670588
dc.identifier.scopus2-s2.0-84863530675


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