Приказ основних података о документу

The association of V249I and T280M fractalkine receptor haplotypes with disease course of multiple sclerosis

dc.creatorStojković, Ljiljana S.
dc.creatorĐurić, Tamara
dc.creatorStanković, Aleksandra
dc.creatorDinčić, Evica
dc.creatorStančić, Olja
dc.creatorVeljković, Nevena V.
dc.creatorAlavantić, Dragan
dc.creatorŽivković, Maja
dc.date.accessioned2018-03-01T22:29:11Z
dc.date.available2018-03-01T22:29:11Z
dc.date.issued2012
dc.identifier.issn0165-5728
dc.identifier.issn1872-8421
dc.identifier.urihttps://vinar.vin.bg.ac.rs/handle/123456789/4841
dc.description.abstractWe investigated the association of CX3CR1 genotypes/haplotypes with MS and performed the prediction analysis of protein sequence variants effects on CX3CL1/CX3CR1 interaction. We found no association of CX3CR1 with MS susceptibility. Frequency of I249T280 haplotype was significantly lower in SP compared to RR patients (RR GT 10 years, OR=0.30, 95%CI=0.11-0.79, p=0.01: OR=0.53, 95%CI=0.18-1.56, p=0.2, in sP LT 10 years vs. RR GT 10 years). Prediction analysis showed that I249 T280 protein variant would significantly affect CX3CL1/CX3CR1 interaction. Our results suggest that CX3CR1 I249T280 haplotype could have protective effect for switch to SP MS. Further research is warranted to validate and replicate currently observed results. (C) 2012 Elsevier B.V. All rights reserved.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175085/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173001/RS//
dc.rightsrestrictedAccessen
dc.sourceJournal of Neuroimmunologyen
dc.subjectCX3CR1en
dc.subjectPolymorphismen
dc.subjectV249Ien
dc.subjectT280Men
dc.subjectHaplotypesen
dc.subjectMultiple sclerosisen
dc.subjectClinical courseen
dc.titleThe association of V249I and T280M fractalkine receptor haplotypes with disease course of multiple sclerosisen
dc.typearticleen
dcterms.abstractЂурић Тамара; Стојковић Љиљана; Aлавантић Драган; Станциц, Оља; Динциц, Евица; Станковић Aлександра; Вељковић Невена В.; Живковић Маја;
dc.citation.volume245
dc.citation.issue1-2
dc.citation.spage87
dc.citation.epage92
dc.identifier.wos000303908100012
dc.identifier.doi10.1016/j.jneuroim.2011.12.028
dc.citation.rankM22
dc.identifier.pmid22261545
dc.identifier.scopus2-s2.0-84859637639


Документи

ДатотекеВеличинаФорматПреглед

Уз овај запис нема датотека.

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу