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90Y-labeled tin fluoride colloid as a promising therapeutic agent: Preparation, characterization, and biological study in rats
dc.creator | Janković, Drina | |
dc.creator | Vranješ-Đurić, Sanja | |
dc.creator | Đokić, Divna Đ. | |
dc.creator | Marković, Mirjana | |
dc.creator | Ajdinovic, Boris | |
dc.creator | Jaukovic, Ljiljana | |
dc.creator | Nikolić, Nadežda S. | |
dc.date.accessioned | 2018-03-01T22:25:42Z | |
dc.date.available | 2018-03-01T22:25:42Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 0022-3549 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/4800 | |
dc.description.abstract | In this study, tin fluoride colloid (SnF-c) was prepared, labeled with yttrium-90 (90Y), and characterized with respect to its physicochemical properties and biological behavior in an animal model. Particle size of SnF-c, at constant concentration of SnF2, was dependent on pH, concentration of sodium fluoride (NaF), temperature, and time. The particle size of SnF-c decreased with an increase in NaF concentration and a decrease in reaction mixture pH. Radiolabeling yield of 90YSnF-c at higher temperature increased and it was greater than 98% for the preparation at 95 degrees C. The 90YSnF-c demonstrated high in vitro stability both in human serum and human synovial fluid at 37 degrees C up to 7 days. In vivo distribution studies in healthy male Wistar rats of 90YSnF-c (particles LT 1 mu m), following intravenous administration, revealed that the localization takes place preferably in the liver. The 90YSnF-c (particles GT 1 mu m) was well retained in the synovial space for 96 h after intra-articular injection, whereas leakage of 90Y from the joint was 1.96% over this period. Because of high labeling yield and stability, 90YSnF-c might be a promising agent for radiosynovectomy or therapy of liver malignancies. (C) 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 101:21942203, 2012 | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45015/RS// | |
dc.relation | Cost Action [BM607], IAEA, CRP [14827/R0] | |
dc.rights | restrictedAccess | en |
dc.source | Journal of Pharmaceutical Sciences | en |
dc.subject | 90Y | en |
dc.subject | radiolabeling | en |
dc.subject | tin(II) fluoride colloid | en |
dc.subject | chromatography | en |
dc.subject | particle size | en |
dc.subject | stability | en |
dc.subject | microscopy | en |
dc.subject | light-scattering | en |
dc.subject | radiotherapy | en |
dc.title | 90Y-labeled tin fluoride colloid as a promising therapeutic agent: Preparation, characterization, and biological study in rats | en |
dc.type | article | en |
dcterms.abstract | Aјдиновиц, Борис; Николиц, Надезда; Јауковиц, Љиљана; Дјокиц, Дивна; Марковић Мирјана; Врањеш-Дјурић Сања; Јанковић Дрина; | |
dc.citation.volume | 101 | |
dc.citation.issue | 6 | |
dc.citation.spage | 2194 | |
dc.citation.epage | 2203 | |
dc.identifier.wos | 000302800300024 | |
dc.identifier.doi | 10.1002/jps.23114 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 22415405 | |
dc.identifier.scopus | 2-s2.0-84859767748 |
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