Age-related deterioration in trabecular bone mechanical properties at material level: Nanoindentation study of the femoral neck in women by using AFM
Nema prikaza
Autori
Milovanović, PetarPotočnik, Jelena
Djonic, Danijela
Nikolic, Slobodan
Živković, Vladimir
Đurić, Marija
Rakočević, Zlatko Lj.
Članak u časopisu
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Despite general belief that the mechanical properties of bone material contribute to whole bone strength, it is still obscure what the age effects are on mechanical behavior of the bone material, particularly in the case of the femoral neck trabeculae. In this study, atomic force microscopy was used for imaging and measuring the size of mineral grains, as well as nano-scale mechanical characterization (nanoindentation) of the bone mineralized matrix of trabeculae, with the aim to explore the age effects on bone elasticity and give new insight into age-related bone fragility. The bone samples in this study comprised trabecular bone specimens of the femoral neck region, collected from eight skeletal healthy women (five young adults: 27-38 yrs., three elderly: 83-94 yrs.) at autopsy. Bone trabeculae in the elderly displayed a higher modulus and nanohardness, signifying a decreased amount of energy that can be accommodated by the bone tissue during loading. Regression analysis revealed tha...t nearly 65% of variability in the bone matrix elastic modulus can be statistically explained by the changes in size of the matrix mineral grains. This study revealed that the bone trabeculae of elderly women express less elastic behavior at the material level, which makes them more vulnerable to unusual impact loads originating from a fall. The observed age-related structural and mechanical alteration at the bone material level adds new evidence for understanding why hip fractures are more frequent in elderly women. (C) 2011 Elsevier Inc. All rights reserved.
Ključne reči:
Bone / Nanoindentation / Atomic force microscopy / Trabecular bone / Aging / FemurIzvor:
Experimental Gerontology, 2012, 47, 2, 154-159Finansiranje / projekti:
- Funkcionalni, funkcionalizovani i usavršeni nano materijali (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45005)
DOI: 10.1016/j.exger.2011.11.011
ISSN: 0531-5565; 1873-6815
PubMed: 22155690
WoS: 000300918500005
Scopus: 2-s2.0-84856228321
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Milovanović, Petar AU - Potočnik, Jelena AU - Djonic, Danijela AU - Nikolic, Slobodan AU - Živković, Vladimir AU - Đurić, Marija AU - Rakočević, Zlatko Lj. PY - 2012 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4716 AB - Despite general belief that the mechanical properties of bone material contribute to whole bone strength, it is still obscure what the age effects are on mechanical behavior of the bone material, particularly in the case of the femoral neck trabeculae. In this study, atomic force microscopy was used for imaging and measuring the size of mineral grains, as well as nano-scale mechanical characterization (nanoindentation) of the bone mineralized matrix of trabeculae, with the aim to explore the age effects on bone elasticity and give new insight into age-related bone fragility. The bone samples in this study comprised trabecular bone specimens of the femoral neck region, collected from eight skeletal healthy women (five young adults: 27-38 yrs., three elderly: 83-94 yrs.) at autopsy. Bone trabeculae in the elderly displayed a higher modulus and nanohardness, signifying a decreased amount of energy that can be accommodated by the bone tissue during loading. Regression analysis revealed that nearly 65% of variability in the bone matrix elastic modulus can be statistically explained by the changes in size of the matrix mineral grains. This study revealed that the bone trabeculae of elderly women express less elastic behavior at the material level, which makes them more vulnerable to unusual impact loads originating from a fall. The observed age-related structural and mechanical alteration at the bone material level adds new evidence for understanding why hip fractures are more frequent in elderly women. (C) 2011 Elsevier Inc. All rights reserved. T2 - Experimental Gerontology T1 - Age-related deterioration in trabecular bone mechanical properties at material level: Nanoindentation study of the femoral neck in women by using AFM VL - 47 IS - 2 SP - 154 EP - 159 DO - 10.1016/j.exger.2011.11.011 ER -
@article{ author = "Milovanović, Petar and Potočnik, Jelena and Djonic, Danijela and Nikolic, Slobodan and Živković, Vladimir and Đurić, Marija and Rakočević, Zlatko Lj.", year = "2012", abstract = "Despite general belief that the mechanical properties of bone material contribute to whole bone strength, it is still obscure what the age effects are on mechanical behavior of the bone material, particularly in the case of the femoral neck trabeculae. In this study, atomic force microscopy was used for imaging and measuring the size of mineral grains, as well as nano-scale mechanical characterization (nanoindentation) of the bone mineralized matrix of trabeculae, with the aim to explore the age effects on bone elasticity and give new insight into age-related bone fragility. The bone samples in this study comprised trabecular bone specimens of the femoral neck region, collected from eight skeletal healthy women (five young adults: 27-38 yrs., three elderly: 83-94 yrs.) at autopsy. Bone trabeculae in the elderly displayed a higher modulus and nanohardness, signifying a decreased amount of energy that can be accommodated by the bone tissue during loading. Regression analysis revealed that nearly 65% of variability in the bone matrix elastic modulus can be statistically explained by the changes in size of the matrix mineral grains. This study revealed that the bone trabeculae of elderly women express less elastic behavior at the material level, which makes them more vulnerable to unusual impact loads originating from a fall. The observed age-related structural and mechanical alteration at the bone material level adds new evidence for understanding why hip fractures are more frequent in elderly women. (C) 2011 Elsevier Inc. All rights reserved.", journal = "Experimental Gerontology", title = "Age-related deterioration in trabecular bone mechanical properties at material level: Nanoindentation study of the femoral neck in women by using AFM", volume = "47", number = "2", pages = "154-159", doi = "10.1016/j.exger.2011.11.011" }
Milovanović, P., Potočnik, J., Djonic, D., Nikolic, S., Živković, V., Đurić, M.,& Rakočević, Z. Lj.. (2012). Age-related deterioration in trabecular bone mechanical properties at material level: Nanoindentation study of the femoral neck in women by using AFM. in Experimental Gerontology, 47(2), 154-159. https://doi.org/10.1016/j.exger.2011.11.011
Milovanović P, Potočnik J, Djonic D, Nikolic S, Živković V, Đurić M, Rakočević ZL. Age-related deterioration in trabecular bone mechanical properties at material level: Nanoindentation study of the femoral neck in women by using AFM. in Experimental Gerontology. 2012;47(2):154-159. doi:10.1016/j.exger.2011.11.011 .
Milovanović, Petar, Potočnik, Jelena, Djonic, Danijela, Nikolic, Slobodan, Živković, Vladimir, Đurić, Marija, Rakočević, Zlatko Lj., "Age-related deterioration in trabecular bone mechanical properties at material level: Nanoindentation study of the femoral neck in women by using AFM" in Experimental Gerontology, 47, no. 2 (2012):154-159, https://doi.org/10.1016/j.exger.2011.11.011 . .