Different Sensitivity of Various Brain Structures to Thioacetamide-Induced Lipid Peroxidation
Нема приказа
Аутори
Mladenovic, DusanKrstić, Danijela Z.
Čolović, Mirjana B.
Radosavljevic, Tatjana
Rašić-Marković, Aleksandra
Hrnčić, Dragan
Macut, Djuro
Stanojlović, Olivera
Чланак у часопису
Метаподаци
Приказ свих података о документуАпстракт
Thioacetamide (TAA) exerts hepatotoxic, neurotoxic and carcinogenic effects. The aim of our study was to investigate the effects of TAA on lipid peroxidation and catalase activity in various rat brain regions. Male Wistar rats were divided into following groups: 1. control, saline-treated; 2. thioacetamide-treated groups, TAA(300) (300 mg/kg), TAA(600) (600 mg/kg) and TAA(900) (900 mg/kg). Daily dose of TAA (300 mg/kg) was administered intraperitoneally once (TAA(300)), twice (TAA(600)) and three times (TAA(900)) in consecutive days. Brain samples were collected 24 h after the last dose of TAA and malondialdehyde (MDA) level and catalase activity were determined in cortex, brainstem and hippocampus. MDA level was significantly increased while catalase activity was significantly lower in all brain regions in TAA(900) group in comparison with control group. In TAA(600) MDA level was increased in the brainstem and cortex when compared to control (p LT 0.01). The same dose of TAA(600) mg/k...g induced a significant decline in catalase activity in the brainstem and cortex and an increase in its activity in the hippocampus when compared to control (p LT 0.01). In TAA(300) an increase in MDA level was evident only in the brainstem. Catalase activity was significantly higher in the cortex and hippocampus in TAA(300) group in comparison with control (p LT 0.01). Based on these results, it may be concluded that various rat brain regions have different sensitivity to TAA-induced lipid peroxidation with hippocampus being less sensitive than cerebral cortex and brainstem.
Кључне речи:
Brainstem / catalase / hepatic encephalopathy / hippocampus / lipid peroxidation / rats / thioacetamideИзвор:
Medicinal Chemistry, 2012, 8, 1, 52-58Финансирање / пројекти:
- Развој анималних модела епилепсије и тестирање конвулзивних и антиконвулзивних супстанци (RS-MESTD-Basic Research (BR or ON)-175032)
DOI: 10.2174/157340612799278603
ISSN: 1573-4064
PubMed: 22420551
WoS: 000300415900009
Scopus: 2-s2.0-84858252478
Колекције
Институција/група
VinčaTY - JOUR AU - Mladenovic, Dusan AU - Krstić, Danijela Z. AU - Čolović, Mirjana B. AU - Radosavljevic, Tatjana AU - Rašić-Marković, Aleksandra AU - Hrnčić, Dragan AU - Macut, Djuro AU - Stanojlović, Olivera PY - 2012 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4696 AB - Thioacetamide (TAA) exerts hepatotoxic, neurotoxic and carcinogenic effects. The aim of our study was to investigate the effects of TAA on lipid peroxidation and catalase activity in various rat brain regions. Male Wistar rats were divided into following groups: 1. control, saline-treated; 2. thioacetamide-treated groups, TAA(300) (300 mg/kg), TAA(600) (600 mg/kg) and TAA(900) (900 mg/kg). Daily dose of TAA (300 mg/kg) was administered intraperitoneally once (TAA(300)), twice (TAA(600)) and three times (TAA(900)) in consecutive days. Brain samples were collected 24 h after the last dose of TAA and malondialdehyde (MDA) level and catalase activity were determined in cortex, brainstem and hippocampus. MDA level was significantly increased while catalase activity was significantly lower in all brain regions in TAA(900) group in comparison with control group. In TAA(600) MDA level was increased in the brainstem and cortex when compared to control (p LT 0.01). The same dose of TAA(600) mg/kg induced a significant decline in catalase activity in the brainstem and cortex and an increase in its activity in the hippocampus when compared to control (p LT 0.01). In TAA(300) an increase in MDA level was evident only in the brainstem. Catalase activity was significantly higher in the cortex and hippocampus in TAA(300) group in comparison with control (p LT 0.01). Based on these results, it may be concluded that various rat brain regions have different sensitivity to TAA-induced lipid peroxidation with hippocampus being less sensitive than cerebral cortex and brainstem. T2 - Medicinal Chemistry T1 - Different Sensitivity of Various Brain Structures to Thioacetamide-Induced Lipid Peroxidation VL - 8 IS - 1 SP - 52 EP - 58 DO - 10.2174/157340612799278603 ER -
@article{ author = "Mladenovic, Dusan and Krstić, Danijela Z. and Čolović, Mirjana B. and Radosavljevic, Tatjana and Rašić-Marković, Aleksandra and Hrnčić, Dragan and Macut, Djuro and Stanojlović, Olivera", year = "2012", abstract = "Thioacetamide (TAA) exerts hepatotoxic, neurotoxic and carcinogenic effects. The aim of our study was to investigate the effects of TAA on lipid peroxidation and catalase activity in various rat brain regions. Male Wistar rats were divided into following groups: 1. control, saline-treated; 2. thioacetamide-treated groups, TAA(300) (300 mg/kg), TAA(600) (600 mg/kg) and TAA(900) (900 mg/kg). Daily dose of TAA (300 mg/kg) was administered intraperitoneally once (TAA(300)), twice (TAA(600)) and three times (TAA(900)) in consecutive days. Brain samples were collected 24 h after the last dose of TAA and malondialdehyde (MDA) level and catalase activity were determined in cortex, brainstem and hippocampus. MDA level was significantly increased while catalase activity was significantly lower in all brain regions in TAA(900) group in comparison with control group. In TAA(600) MDA level was increased in the brainstem and cortex when compared to control (p LT 0.01). The same dose of TAA(600) mg/kg induced a significant decline in catalase activity in the brainstem and cortex and an increase in its activity in the hippocampus when compared to control (p LT 0.01). In TAA(300) an increase in MDA level was evident only in the brainstem. Catalase activity was significantly higher in the cortex and hippocampus in TAA(300) group in comparison with control (p LT 0.01). Based on these results, it may be concluded that various rat brain regions have different sensitivity to TAA-induced lipid peroxidation with hippocampus being less sensitive than cerebral cortex and brainstem.", journal = "Medicinal Chemistry", title = "Different Sensitivity of Various Brain Structures to Thioacetamide-Induced Lipid Peroxidation", volume = "8", number = "1", pages = "52-58", doi = "10.2174/157340612799278603" }
Mladenovic, D., Krstić, D. Z., Čolović, M. B., Radosavljevic, T., Rašić-Marković, A., Hrnčić, D., Macut, D.,& Stanojlović, O.. (2012). Different Sensitivity of Various Brain Structures to Thioacetamide-Induced Lipid Peroxidation. in Medicinal Chemistry, 8(1), 52-58. https://doi.org/10.2174/157340612799278603
Mladenovic D, Krstić DZ, Čolović MB, Radosavljevic T, Rašić-Marković A, Hrnčić D, Macut D, Stanojlović O. Different Sensitivity of Various Brain Structures to Thioacetamide-Induced Lipid Peroxidation. in Medicinal Chemistry. 2012;8(1):52-58. doi:10.2174/157340612799278603 .
Mladenovic, Dusan, Krstić, Danijela Z., Čolović, Mirjana B., Radosavljevic, Tatjana, Rašić-Marković, Aleksandra, Hrnčić, Dragan, Macut, Djuro, Stanojlović, Olivera, "Different Sensitivity of Various Brain Structures to Thioacetamide-Induced Lipid Peroxidation" in Medicinal Chemistry, 8, no. 1 (2012):52-58, https://doi.org/10.2174/157340612799278603 . .