A new, simple, green, and one-pot four-component synthesis of bare and poly(alpha,gamma,l-glutamic acid)-capped silver nanoparticles
Škapin, Srečo Davor
Jovanović, Uroš D.
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A simple and green chemical method has been developed to synthesize stable bare and capped silver nanoparticles based on the reduction of silver ions by glucose and capping by poly(alpha,gamma,l-glutamic acid) (PGA). The use of ammonia during synthesis was avoided. PGA has had a dual role in the synthesis and was used as a capping agent to make the silver nanoparticle more biocompatible and to protect the nanoparticles from agglomerating in the liquid medium. The synthesized PGA-capped silver nanoparticles in the size range 5-45 nm were stable over long periods of time, without signs of precipitation. Morphological examination has shown that the silver nanoparticles had a nearly spherical, multiply twinned structure. The effects of the reaction temperature and the reaction time during the synthesis were investigated too. The biocompatibility of the PGA-capped silver nanoparticles is discussed in terms of in vitro toxicity with human intestinal Caco-2 cells. The samples were characteriz...ed by UV-Visible spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, and zeta potential measurements.
Keywords:Silver nanoparticles / Green method / Poly(alpha,gamma,L-glutamic acid) / Capping agent / In vitro toxicity
Source:Colloid and Polymer Science, 2012, 290, 3, 221-231
- Molecular designing of nanoparticles with controlled morphological and physicochemical characteristics and functional materials based on them (RS-45004)
- Desai Lab at UCSF, NIH [K99-DE021416]