Modeling of relay helix functional dynamics and feasibility of experimental verification by neutron scattering
Апстракт
Cellular long-range transport involves motor proteins (MPs) (especially, kinesin and myosin) which contain a so-called relay helix. Its motion is of crucial importance to the conversion of chemical energy released in ATP hydrolysis into the coordinated mechanical movement of the entire motor protein. In this paper, we propose two combined nonlinear mechanisms for this particular functional activity and suggest the application of neutron scattering assays to experimentally determine the incoherent dynamic structure factor S(q, omega). We argue that this type of experiment is not only feasible but it could offer significant insights into the mechanism of MP function at a molecular level.
Извор:
Chaos, 2011, 21, 4Финансирање / пројекти:
- Утицај елементарних ексцитација и конформација на физичка својства нових материјала базираних на јако корелисаним нискодимензионалним системима (RS-MESTD-Basic Research (BR or ON)-171009)
- Фотоника микро и нано структурних материјала (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45010)
- Serbian Academy of Sciences and Arts, NSERC (Canada)
DOI: 10.1063/1.3665091
ISSN: 1054-1500
PubMed: 22225372
WoS: 000298639100043
Scopus: 2-s2.0-84855265273
Колекције
Институција/група
VinčaTY - JOUR AU - Satarić, Miljko V. AU - Zdravković, Slobodan AU - Tuszynski, Jack A. PY - 2011 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4628 AB - Cellular long-range transport involves motor proteins (MPs) (especially, kinesin and myosin) which contain a so-called relay helix. Its motion is of crucial importance to the conversion of chemical energy released in ATP hydrolysis into the coordinated mechanical movement of the entire motor protein. In this paper, we propose two combined nonlinear mechanisms for this particular functional activity and suggest the application of neutron scattering assays to experimentally determine the incoherent dynamic structure factor S(q, omega). We argue that this type of experiment is not only feasible but it could offer significant insights into the mechanism of MP function at a molecular level. T2 - Chaos T1 - Modeling of relay helix functional dynamics and feasibility of experimental verification by neutron scattering VL - 21 IS - 4 DO - 10.1063/1.3665091 ER -
@article{ author = "Satarić, Miljko V. and Zdravković, Slobodan and Tuszynski, Jack A.", year = "2011", abstract = "Cellular long-range transport involves motor proteins (MPs) (especially, kinesin and myosin) which contain a so-called relay helix. Its motion is of crucial importance to the conversion of chemical energy released in ATP hydrolysis into the coordinated mechanical movement of the entire motor protein. In this paper, we propose two combined nonlinear mechanisms for this particular functional activity and suggest the application of neutron scattering assays to experimentally determine the incoherent dynamic structure factor S(q, omega). We argue that this type of experiment is not only feasible but it could offer significant insights into the mechanism of MP function at a molecular level.", journal = "Chaos", title = "Modeling of relay helix functional dynamics and feasibility of experimental verification by neutron scattering", volume = "21", number = "4", doi = "10.1063/1.3665091" }
Satarić, M. V., Zdravković, S.,& Tuszynski, J. A.. (2011). Modeling of relay helix functional dynamics and feasibility of experimental verification by neutron scattering. in Chaos, 21(4). https://doi.org/10.1063/1.3665091
Satarić MV, Zdravković S, Tuszynski JA. Modeling of relay helix functional dynamics and feasibility of experimental verification by neutron scattering. in Chaos. 2011;21(4). doi:10.1063/1.3665091 .
Satarić, Miljko V., Zdravković, Slobodan, Tuszynski, Jack A., "Modeling of relay helix functional dynamics and feasibility of experimental verification by neutron scattering" in Chaos, 21, no. 4 (2011), https://doi.org/10.1063/1.3665091 . .