Effects of Levothyroxine Replacement Therapy on Parameters of Metabolic Syndrome and Atherosclerosis in Hypothyroid Patients: A Prospective Pilot Study
2015
Authors
Gluvić, ZoranSudar, Emina
Tica, Jelena
Jovanović, Aleksandra
Zafirović, Sonja
Tomasevic, Ratko
Isenović, Esma R.
Article (Published version)
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The aim of this study was to investigate the effect of levothyroxine (LT4) replacement therapy during three months on some parameters of metabolic syndrome and atherosclerosis in patients with increased thyroid-stimulating hormone (TSH) level. This study included a group of 30 female patients with TSH level GT 4mIU/L and 15 matched healthy controls. Intima media complex thickness (IMCT) and peak systolic flow velocity (PSFV) of superficial femoral artery were determined by Color Doppler scan. In hypothyroid subjects, BMI, SBP, DBP, and TSH were significantly increased versus controls and decreased after LT4 administration. FT4 was significantly lower in hypothyroid subjects compared with controls and significantly higher by treatment. TC, Tg, HDLC, and LDL-C were similar to controls at baseline but TC and LDL-C were significantly decreased by LH4 treatment. IMCT was significantly increased versus controls at baseline and significantly reduced by treatment. PSFV was similar to controls ...at baseline and significantly decreased on treatment. In this study, we have demonstrated the effects of LT4 replacement therapy during three months of treatment on correction of risk factors of metabolic syndrome and atherosclerosis.
Source:
International Journal of Endocrinology, 2015Funding / projects:
- Hormonal regulation of expression and activity of the nitric oxide synthase and sodium-potassium pump in experimental models of insulin resistance, diabetes and cardiovascular disorders (RS-MESTD-Basic Research (BR or ON)-173033)
- Clinical Center Zemun
DOI: 10.1155/2015/147070
ISSN: 1687-8337; 1687-8345
WoS: 000351387000001
Scopus: 2-s2.0-84925433253
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VinčaTY - JOUR AU - Gluvić, Zoran AU - Sudar, Emina AU - Tica, Jelena AU - Jovanović, Aleksandra AU - Zafirović, Sonja AU - Tomasevic, Ratko AU - Isenović, Esma R. PY - 2015 UR - https://vinar.vin.bg.ac.rs/handle/123456789/459 AB - The aim of this study was to investigate the effect of levothyroxine (LT4) replacement therapy during three months on some parameters of metabolic syndrome and atherosclerosis in patients with increased thyroid-stimulating hormone (TSH) level. This study included a group of 30 female patients with TSH level GT 4mIU/L and 15 matched healthy controls. Intima media complex thickness (IMCT) and peak systolic flow velocity (PSFV) of superficial femoral artery were determined by Color Doppler scan. In hypothyroid subjects, BMI, SBP, DBP, and TSH were significantly increased versus controls and decreased after LT4 administration. FT4 was significantly lower in hypothyroid subjects compared with controls and significantly higher by treatment. TC, Tg, HDLC, and LDL-C were similar to controls at baseline but TC and LDL-C were significantly decreased by LH4 treatment. IMCT was significantly increased versus controls at baseline and significantly reduced by treatment. PSFV was similar to controls at baseline and significantly decreased on treatment. In this study, we have demonstrated the effects of LT4 replacement therapy during three months of treatment on correction of risk factors of metabolic syndrome and atherosclerosis. T2 - International Journal of Endocrinology T1 - Effects of Levothyroxine Replacement Therapy on Parameters of Metabolic Syndrome and Atherosclerosis in Hypothyroid Patients: A Prospective Pilot Study DO - 10.1155/2015/147070 ER -
@article{ author = "Gluvić, Zoran and Sudar, Emina and Tica, Jelena and Jovanović, Aleksandra and Zafirović, Sonja and Tomasevic, Ratko and Isenović, Esma R.", year = "2015", abstract = "The aim of this study was to investigate the effect of levothyroxine (LT4) replacement therapy during three months on some parameters of metabolic syndrome and atherosclerosis in patients with increased thyroid-stimulating hormone (TSH) level. This study included a group of 30 female patients with TSH level GT 4mIU/L and 15 matched healthy controls. Intima media complex thickness (IMCT) and peak systolic flow velocity (PSFV) of superficial femoral artery were determined by Color Doppler scan. In hypothyroid subjects, BMI, SBP, DBP, and TSH were significantly increased versus controls and decreased after LT4 administration. FT4 was significantly lower in hypothyroid subjects compared with controls and significantly higher by treatment. TC, Tg, HDLC, and LDL-C were similar to controls at baseline but TC and LDL-C were significantly decreased by LH4 treatment. IMCT was significantly increased versus controls at baseline and significantly reduced by treatment. PSFV was similar to controls at baseline and significantly decreased on treatment. In this study, we have demonstrated the effects of LT4 replacement therapy during three months of treatment on correction of risk factors of metabolic syndrome and atherosclerosis.", journal = "International Journal of Endocrinology", title = "Effects of Levothyroxine Replacement Therapy on Parameters of Metabolic Syndrome and Atherosclerosis in Hypothyroid Patients: A Prospective Pilot Study", doi = "10.1155/2015/147070" }
Gluvić, Z., Sudar, E., Tica, J., Jovanović, A., Zafirović, S., Tomasevic, R.,& Isenović, E. R.. (2015). Effects of Levothyroxine Replacement Therapy on Parameters of Metabolic Syndrome and Atherosclerosis in Hypothyroid Patients: A Prospective Pilot Study. in International Journal of Endocrinology. https://doi.org/10.1155/2015/147070
Gluvić Z, Sudar E, Tica J, Jovanović A, Zafirović S, Tomasevic R, Isenović ER. Effects of Levothyroxine Replacement Therapy on Parameters of Metabolic Syndrome and Atherosclerosis in Hypothyroid Patients: A Prospective Pilot Study. in International Journal of Endocrinology. 2015;. doi:10.1155/2015/147070 .
Gluvić, Zoran, Sudar, Emina, Tica, Jelena, Jovanović, Aleksandra, Zafirović, Sonja, Tomasevic, Ratko, Isenović, Esma R., "Effects of Levothyroxine Replacement Therapy on Parameters of Metabolic Syndrome and Atherosclerosis in Hypothyroid Patients: A Prospective Pilot Study" in International Journal of Endocrinology (2015), https://doi.org/10.1155/2015/147070 . .