Benzimidazole derivatives as NSO ligands for the fac-[M(CO)(3)](+) (M = Re, Tc-99m)
Nema prikaza
Autori
Tsotakos, T.Tsoukalas, C.
Patsis, G.
Panagiotopoulou, A.
Nikolić, Nadežda S.
Janković, Drina
Đokić, Divna Đ.
Raptopoulou, C. P.
Terzis, A.
Papagiannopoulou, D.
Pelecanou, M.
Papadopoulos, M.
Pirmettis, Ioannis
Članak u časopisu
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Two rhenium(I) tricarbonyl complexes with the tridentate monoanionic NSO ligands, 4-(benzimidazol-2-yl)-3-thiabutanoic acid (complex 3) and [1-(11-carboxyundecanyl)-4-(benzimidazol-2-yl)]-3-thiabutanoic acid (complex 4) were synthesized and characterized by spectroscopic methods and elemental analysis. X-ray crystallographic analysis of complex 3 revealed a distorted octahedral geometry around rhenium defined by the three facially bound CO groups and the NSO donor atom set of the tridentate ligand. The analogous technetium-99m complexes (complexes 5 and 6) were also prepared quantitatively by reaction of the NSO ligands with the fac-[Tc-99m(H2O)(3)(CO)(3)](+) synthon and their identity was established by chromatographic comparison to their rhenium congeners. Biodistribution in mice of complex 6 bearing the fatty acid chain showed significant heart uptake (6.26 +/- 0.79% ID/g p.i.) at 1 min accompanied, however, with a heart: blood ratio below 1. (C) 2011 Elsevier B. V. All rights reser...ved.
Ključne reči:
Technetium-99m / Rhenium / Tricarbonyl / Fatty acidIzvor:
Inorganica Chimica Acta, 2011, 377, 1, 62-68Finansiranje / projekti:
- GSRT, Hellenic Ministry of Development, Greek-Serbian Bilateral Co-operation Research Project [709]
DOI: 10.1016/j.ica.2011.07.035
ISSN: 0020-1693
WoS: 000296523400010
Scopus: 2-s2.0-80053921602
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Tsotakos, T. AU - Tsoukalas, C. AU - Patsis, G. AU - Panagiotopoulou, A. AU - Nikolić, Nadežda S. AU - Janković, Drina AU - Đokić, Divna Đ. AU - Raptopoulou, C. P. AU - Terzis, A. AU - Papagiannopoulou, D. AU - Pelecanou, M. AU - Papadopoulos, M. AU - Pirmettis, Ioannis PY - 2011 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4546 AB - Two rhenium(I) tricarbonyl complexes with the tridentate monoanionic NSO ligands, 4-(benzimidazol-2-yl)-3-thiabutanoic acid (complex 3) and [1-(11-carboxyundecanyl)-4-(benzimidazol-2-yl)]-3-thiabutanoic acid (complex 4) were synthesized and characterized by spectroscopic methods and elemental analysis. X-ray crystallographic analysis of complex 3 revealed a distorted octahedral geometry around rhenium defined by the three facially bound CO groups and the NSO donor atom set of the tridentate ligand. The analogous technetium-99m complexes (complexes 5 and 6) were also prepared quantitatively by reaction of the NSO ligands with the fac-[Tc-99m(H2O)(3)(CO)(3)](+) synthon and their identity was established by chromatographic comparison to their rhenium congeners. Biodistribution in mice of complex 6 bearing the fatty acid chain showed significant heart uptake (6.26 +/- 0.79% ID/g p.i.) at 1 min accompanied, however, with a heart: blood ratio below 1. (C) 2011 Elsevier B. V. All rights reserved. T2 - Inorganica Chimica Acta T1 - Benzimidazole derivatives as NSO ligands for the fac-[M(CO)(3)](+) (M = Re, Tc-99m) VL - 377 IS - 1 SP - 62 EP - 68 DO - 10.1016/j.ica.2011.07.035 ER -
@article{ author = "Tsotakos, T. and Tsoukalas, C. and Patsis, G. and Panagiotopoulou, A. and Nikolić, Nadežda S. and Janković, Drina and Đokić, Divna Đ. and Raptopoulou, C. P. and Terzis, A. and Papagiannopoulou, D. and Pelecanou, M. and Papadopoulos, M. and Pirmettis, Ioannis", year = "2011", abstract = "Two rhenium(I) tricarbonyl complexes with the tridentate monoanionic NSO ligands, 4-(benzimidazol-2-yl)-3-thiabutanoic acid (complex 3) and [1-(11-carboxyundecanyl)-4-(benzimidazol-2-yl)]-3-thiabutanoic acid (complex 4) were synthesized and characterized by spectroscopic methods and elemental analysis. X-ray crystallographic analysis of complex 3 revealed a distorted octahedral geometry around rhenium defined by the three facially bound CO groups and the NSO donor atom set of the tridentate ligand. The analogous technetium-99m complexes (complexes 5 and 6) were also prepared quantitatively by reaction of the NSO ligands with the fac-[Tc-99m(H2O)(3)(CO)(3)](+) synthon and their identity was established by chromatographic comparison to their rhenium congeners. Biodistribution in mice of complex 6 bearing the fatty acid chain showed significant heart uptake (6.26 +/- 0.79% ID/g p.i.) at 1 min accompanied, however, with a heart: blood ratio below 1. (C) 2011 Elsevier B. V. All rights reserved.", journal = "Inorganica Chimica Acta", title = "Benzimidazole derivatives as NSO ligands for the fac-[M(CO)(3)](+) (M = Re, Tc-99m)", volume = "377", number = "1", pages = "62-68", doi = "10.1016/j.ica.2011.07.035" }
Tsotakos, T., Tsoukalas, C., Patsis, G., Panagiotopoulou, A., Nikolić, N. S., Janković, D., Đokić, D. Đ., Raptopoulou, C. P., Terzis, A., Papagiannopoulou, D., Pelecanou, M., Papadopoulos, M.,& Pirmettis, I.. (2011). Benzimidazole derivatives as NSO ligands for the fac-[M(CO)(3)](+) (M = Re, Tc-99m). in Inorganica Chimica Acta, 377(1), 62-68. https://doi.org/10.1016/j.ica.2011.07.035
Tsotakos T, Tsoukalas C, Patsis G, Panagiotopoulou A, Nikolić NS, Janković D, Đokić DĐ, Raptopoulou CP, Terzis A, Papagiannopoulou D, Pelecanou M, Papadopoulos M, Pirmettis I. Benzimidazole derivatives as NSO ligands for the fac-[M(CO)(3)](+) (M = Re, Tc-99m). in Inorganica Chimica Acta. 2011;377(1):62-68. doi:10.1016/j.ica.2011.07.035 .
Tsotakos, T., Tsoukalas, C., Patsis, G., Panagiotopoulou, A., Nikolić, Nadežda S., Janković, Drina, Đokić, Divna Đ., Raptopoulou, C. P., Terzis, A., Papagiannopoulou, D., Pelecanou, M., Papadopoulos, M., Pirmettis, Ioannis, "Benzimidazole derivatives as NSO ligands for the fac-[M(CO)(3)](+) (M = Re, Tc-99m)" in Inorganica Chimica Acta, 377, no. 1 (2011):62-68, https://doi.org/10.1016/j.ica.2011.07.035 . .