Peroxisome Proliferator-Activated Receptors and Atherosclerosis
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Soskić, Sanja S.Dobutović, Branislava
Sudar, Emina
Obradović, Milan M.
Nikolić, Dragana
Zarić, Božidarka
Stojanovic, Srdan D.
Stokić, Edita
Mikhailidis, Dimitri P.
Isenović, Esma R.
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The peroxisome proliferator-activated receptors (PPARs) represent the family of 3 nuclear receptor isoforms-PPAR alpha, -gamma, and -delta/beta, which are encoded by different genes. As lipid sensors, they are primarily involved in regulation of lipid metabolism and subsequently in inflammation and atherosclerosis. Atherosclerosis considers accumulation of the cells and extracellular matrix in the vessel wall leading to the formation of atherosclerotic plaque, atherothrombosis, and other vascular complications. Besides existence of natural ligands for PPARs, their more potent synthetic ligands are fibrates and thiazolidindiones. Future investigations should now focus on the mechanisms of PPARs activation, which might present new approaches involved in the antiatherosclerotic effects revealed in this review. In addition, in this review we are presenting latest data from recent performed clinical studies which have focus on novel approach to PPARs agonists as potential therapeutic agents... in the treatment of complex disease such as atherosclerosis.
Keywords:
peroxisome proliferator-activated receptors alpha / atherosclerosis / peroxisome proliferator-activated receptors gamma / atherosclerotic plaqueSource:
Angiology, 2011, 62, 7, 523-534Funding / projects:
- Hormonal regulation of expression and activity of the nitric oxide synthase and sodium-potassium pump in experimental models of insulin resistance, diabetes and cardiovascular disorders (RS-MESTD-Basic Research (BR or ON)-173033)
- The study of physicochemical and biochemical processes in living environment that have impacts on pollution and the investigation of possibilities for minimizing the consequences (RS-MESTD-Basic Research (BR or ON)-172001)
DOI: 10.1177/0003319711401012
ISSN: 0003-3197
PubMed: 21467121
WoS: 000295729400003
Scopus: 2-s2.0-80054761005
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VinčaTY - JOUR AU - Soskić, Sanja S. AU - Dobutović, Branislava AU - Sudar, Emina AU - Obradović, Milan M. AU - Nikolić, Dragana AU - Zarić, Božidarka AU - Stojanovic, Srdan D. AU - Stokić, Edita AU - Mikhailidis, Dimitri P. AU - Isenović, Esma R. PY - 2011 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4519 AB - The peroxisome proliferator-activated receptors (PPARs) represent the family of 3 nuclear receptor isoforms-PPAR alpha, -gamma, and -delta/beta, which are encoded by different genes. As lipid sensors, they are primarily involved in regulation of lipid metabolism and subsequently in inflammation and atherosclerosis. Atherosclerosis considers accumulation of the cells and extracellular matrix in the vessel wall leading to the formation of atherosclerotic plaque, atherothrombosis, and other vascular complications. Besides existence of natural ligands for PPARs, their more potent synthetic ligands are fibrates and thiazolidindiones. Future investigations should now focus on the mechanisms of PPARs activation, which might present new approaches involved in the antiatherosclerotic effects revealed in this review. In addition, in this review we are presenting latest data from recent performed clinical studies which have focus on novel approach to PPARs agonists as potential therapeutic agents in the treatment of complex disease such as atherosclerosis. T2 - Angiology T1 - Peroxisome Proliferator-Activated Receptors and Atherosclerosis VL - 62 IS - 7 SP - 523 EP - 534 DO - 10.1177/0003319711401012 ER -
@article{ author = "Soskić, Sanja S. and Dobutović, Branislava and Sudar, Emina and Obradović, Milan M. and Nikolić, Dragana and Zarić, Božidarka and Stojanovic, Srdan D. and Stokić, Edita and Mikhailidis, Dimitri P. and Isenović, Esma R.", year = "2011", abstract = "The peroxisome proliferator-activated receptors (PPARs) represent the family of 3 nuclear receptor isoforms-PPAR alpha, -gamma, and -delta/beta, which are encoded by different genes. As lipid sensors, they are primarily involved in regulation of lipid metabolism and subsequently in inflammation and atherosclerosis. Atherosclerosis considers accumulation of the cells and extracellular matrix in the vessel wall leading to the formation of atherosclerotic plaque, atherothrombosis, and other vascular complications. Besides existence of natural ligands for PPARs, their more potent synthetic ligands are fibrates and thiazolidindiones. Future investigations should now focus on the mechanisms of PPARs activation, which might present new approaches involved in the antiatherosclerotic effects revealed in this review. In addition, in this review we are presenting latest data from recent performed clinical studies which have focus on novel approach to PPARs agonists as potential therapeutic agents in the treatment of complex disease such as atherosclerosis.", journal = "Angiology", title = "Peroxisome Proliferator-Activated Receptors and Atherosclerosis", volume = "62", number = "7", pages = "523-534", doi = "10.1177/0003319711401012" }
Soskić, S. S., Dobutović, B., Sudar, E., Obradović, M. M., Nikolić, D., Zarić, B., Stojanovic, S. D., Stokić, E., Mikhailidis, D. P.,& Isenović, E. R.. (2011). Peroxisome Proliferator-Activated Receptors and Atherosclerosis. in Angiology, 62(7), 523-534. https://doi.org/10.1177/0003319711401012
Soskić SS, Dobutović B, Sudar E, Obradović MM, Nikolić D, Zarić B, Stojanovic SD, Stokić E, Mikhailidis DP, Isenović ER. Peroxisome Proliferator-Activated Receptors and Atherosclerosis. in Angiology. 2011;62(7):523-534. doi:10.1177/0003319711401012 .
Soskić, Sanja S., Dobutović, Branislava, Sudar, Emina, Obradović, Milan M., Nikolić, Dragana, Zarić, Božidarka, Stojanovic, Srdan D., Stokić, Edita, Mikhailidis, Dimitri P., Isenović, Esma R., "Peroxisome Proliferator-Activated Receptors and Atherosclerosis" in Angiology, 62, no. 7 (2011):523-534, https://doi.org/10.1177/0003319711401012 . .