Do RCAN1 proteins link chronic stress with neurodegeneration?
Апстракт
It has long been suspected that chronic stress can exacerbate, or even cause, disease. We now propose that the RCAN1 gene, which can generate several RCAN1 protein isoforms, may be at least partially responsible for this phenomenon. We review data showing that RCAN1 proteins can be induced by multiple stresses, and present new data also implicating psychosocial/emotional stress in RCAN1 induction. We further show that transgenic mice overexpressing the RCAN1-1L protein exhibit accumulation of hyperphosphorylated tau protein (AT8 antibody), an early precursor to the formation of neurofibrillary tangles and neurodegeneration of the kind seen in Alzheimer disease. We propose that, although transient induction of the RCAN1 gene might protect cells against acute stress, persistent stress may cause chronic RCAN1 overexpression, resulting in serious side effects. Chronically elevated levels of RCAN1 proteins may promote or exacerbate various diseases, including tauopathies such as Alzheimer d...isease. We propose that the mechanism by which stress can lead to these diseases involves the inhibition of calcineurin and the induction of GSK-3 beta by RCAN1 proteins. Both inhibition of calcineurin and induction of GSK-3 beta contribute to accumulation of phosphorylated tau, formation of neurofibrillary tangles, and eventual neurodegeneration.-Ermak, G., Pritchard, M. A., Dronjak, S., Niu, B., Davies, K. J. A. Do RCAN1 proteins link chronic stress with neurodegeneration? FASEB J. 25, 3306-3311 (2011). www.fasebj.org
Кључне речи:
glucocorticoids / tauИзвор:
FASEB Journal, 2011, 25, 10, 3306-3311Финансирање / пројекти:
- NIA NIH HHS [R01 AG016256], NIEHS NIH HHS [R56 ES003598, R01 ES003598]
DOI: 10.1096/fj.11-185728
ISSN: 0892-6638
PubMed: 21680892
WoS: 000295356400003
Scopus: 2-s2.0-80053928996
Колекције
Институција/група
VinčaTY - JOUR AU - Ermak, Gennady AU - Pritchard, Melanie A. AU - Dronjak, Slađana AU - Niu, Brenda AU - Davies, Kelvin J. A. PY - 2011 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4500 AB - It has long been suspected that chronic stress can exacerbate, or even cause, disease. We now propose that the RCAN1 gene, which can generate several RCAN1 protein isoforms, may be at least partially responsible for this phenomenon. We review data showing that RCAN1 proteins can be induced by multiple stresses, and present new data also implicating psychosocial/emotional stress in RCAN1 induction. We further show that transgenic mice overexpressing the RCAN1-1L protein exhibit accumulation of hyperphosphorylated tau protein (AT8 antibody), an early precursor to the formation of neurofibrillary tangles and neurodegeneration of the kind seen in Alzheimer disease. We propose that, although transient induction of the RCAN1 gene might protect cells against acute stress, persistent stress may cause chronic RCAN1 overexpression, resulting in serious side effects. Chronically elevated levels of RCAN1 proteins may promote or exacerbate various diseases, including tauopathies such as Alzheimer disease. We propose that the mechanism by which stress can lead to these diseases involves the inhibition of calcineurin and the induction of GSK-3 beta by RCAN1 proteins. Both inhibition of calcineurin and induction of GSK-3 beta contribute to accumulation of phosphorylated tau, formation of neurofibrillary tangles, and eventual neurodegeneration.-Ermak, G., Pritchard, M. A., Dronjak, S., Niu, B., Davies, K. J. A. Do RCAN1 proteins link chronic stress with neurodegeneration? FASEB J. 25, 3306-3311 (2011). www.fasebj.org T2 - FASEB Journal T1 - Do RCAN1 proteins link chronic stress with neurodegeneration? VL - 25 IS - 10 SP - 3306 EP - 3311 DO - 10.1096/fj.11-185728 ER -
@article{ author = "Ermak, Gennady and Pritchard, Melanie A. and Dronjak, Slađana and Niu, Brenda and Davies, Kelvin J. A.", year = "2011", abstract = "It has long been suspected that chronic stress can exacerbate, or even cause, disease. We now propose that the RCAN1 gene, which can generate several RCAN1 protein isoforms, may be at least partially responsible for this phenomenon. We review data showing that RCAN1 proteins can be induced by multiple stresses, and present new data also implicating psychosocial/emotional stress in RCAN1 induction. We further show that transgenic mice overexpressing the RCAN1-1L protein exhibit accumulation of hyperphosphorylated tau protein (AT8 antibody), an early precursor to the formation of neurofibrillary tangles and neurodegeneration of the kind seen in Alzheimer disease. We propose that, although transient induction of the RCAN1 gene might protect cells against acute stress, persistent stress may cause chronic RCAN1 overexpression, resulting in serious side effects. Chronically elevated levels of RCAN1 proteins may promote or exacerbate various diseases, including tauopathies such as Alzheimer disease. We propose that the mechanism by which stress can lead to these diseases involves the inhibition of calcineurin and the induction of GSK-3 beta by RCAN1 proteins. Both inhibition of calcineurin and induction of GSK-3 beta contribute to accumulation of phosphorylated tau, formation of neurofibrillary tangles, and eventual neurodegeneration.-Ermak, G., Pritchard, M. A., Dronjak, S., Niu, B., Davies, K. J. A. Do RCAN1 proteins link chronic stress with neurodegeneration? FASEB J. 25, 3306-3311 (2011). www.fasebj.org", journal = "FASEB Journal", title = "Do RCAN1 proteins link chronic stress with neurodegeneration?", volume = "25", number = "10", pages = "3306-3311", doi = "10.1096/fj.11-185728" }
Ermak, G., Pritchard, M. A., Dronjak, S., Niu, B.,& Davies, K. J. A.. (2011). Do RCAN1 proteins link chronic stress with neurodegeneration?. in FASEB Journal, 25(10), 3306-3311. https://doi.org/10.1096/fj.11-185728
Ermak G, Pritchard MA, Dronjak S, Niu B, Davies KJA. Do RCAN1 proteins link chronic stress with neurodegeneration?. in FASEB Journal. 2011;25(10):3306-3311. doi:10.1096/fj.11-185728 .
Ermak, Gennady, Pritchard, Melanie A., Dronjak, Slađana, Niu, Brenda, Davies, Kelvin J. A., "Do RCAN1 proteins link chronic stress with neurodegeneration?" in FASEB Journal, 25, no. 10 (2011):3306-3311, https://doi.org/10.1096/fj.11-185728 . .