Differential in Vivo Regulation of Th and Dbh Mrna in Rat Atria By Maprotiline and Fluoxetine
Abstract
It is well known that antidepressants affect central monoaminergic neurotransmission and that they also modulate hormone release in peripheral tissues. Repeated maprotiline (a noradrenaline reuptake inhibitor) and fluoxetine (a serotonin reuptake inhibitor) treatment on gene expression of the catecholamine biosynthetic enzymes were examined in rat atria and ventricles in vivo. Maprotiline decreased the gene expression of tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DBH) in the rat atrium. Fluoxetine increased gene expression of TH and DBH, but not of phenylethanolamine N-methyltransferase (PNMT). Chronic application of antidepressants did not change the expression of these enzymes in the ventricles. We conclude that repeated administration of fluoxetine enhances gene transcription of TH and DBH and subsequently stimulates noradrenaline synthesis in rat atria in vivo.
Keywords:
Antidepressants / catecholamine enzymes / gene expression / atria / ventricles / ratsSource:
Archives of Biological Sciences, 2011, 63, 3, 597-601Funding / projects:
- Molecular mechanisms of cellular responses on pathological changes in central neuronal system and peripheral organs of mammals (RS-MESTD-Basic Research (BR or ON)-173044)
- Effects of metabolic and nonmetabolic stressors on the expression and action of neuroendocrine regulators of energy homeostasis (RS-MESTD-Basic Research (BR or ON)-173023)
DOI: 10.2298/ABS1103597S
ISSN: 0354-4664
WoS: 000294400500010
Scopus: 2-s2.0-79961180596
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VinčaTY - JOUR AU - Spasojević, Nataša AU - Jovanović, Predrag AU - Spasojević-Tišma, Vera D. AU - Delic, N. AU - Dronjak, Slađana PY - 2011 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4467 AB - It is well known that antidepressants affect central monoaminergic neurotransmission and that they also modulate hormone release in peripheral tissues. Repeated maprotiline (a noradrenaline reuptake inhibitor) and fluoxetine (a serotonin reuptake inhibitor) treatment on gene expression of the catecholamine biosynthetic enzymes were examined in rat atria and ventricles in vivo. Maprotiline decreased the gene expression of tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DBH) in the rat atrium. Fluoxetine increased gene expression of TH and DBH, but not of phenylethanolamine N-methyltransferase (PNMT). Chronic application of antidepressants did not change the expression of these enzymes in the ventricles. We conclude that repeated administration of fluoxetine enhances gene transcription of TH and DBH and subsequently stimulates noradrenaline synthesis in rat atria in vivo. T2 - Archives of Biological Sciences T1 - Differential in Vivo Regulation of Th and Dbh Mrna in Rat Atria By Maprotiline and Fluoxetine VL - 63 IS - 3 SP - 597 EP - 601 DO - 10.2298/ABS1103597S ER -
@article{ author = "Spasojević, Nataša and Jovanović, Predrag and Spasojević-Tišma, Vera D. and Delic, N. and Dronjak, Slađana", year = "2011", abstract = "It is well known that antidepressants affect central monoaminergic neurotransmission and that they also modulate hormone release in peripheral tissues. Repeated maprotiline (a noradrenaline reuptake inhibitor) and fluoxetine (a serotonin reuptake inhibitor) treatment on gene expression of the catecholamine biosynthetic enzymes were examined in rat atria and ventricles in vivo. Maprotiline decreased the gene expression of tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DBH) in the rat atrium. Fluoxetine increased gene expression of TH and DBH, but not of phenylethanolamine N-methyltransferase (PNMT). Chronic application of antidepressants did not change the expression of these enzymes in the ventricles. We conclude that repeated administration of fluoxetine enhances gene transcription of TH and DBH and subsequently stimulates noradrenaline synthesis in rat atria in vivo.", journal = "Archives of Biological Sciences", title = "Differential in Vivo Regulation of Th and Dbh Mrna in Rat Atria By Maprotiline and Fluoxetine", volume = "63", number = "3", pages = "597-601", doi = "10.2298/ABS1103597S" }
Spasojević, N., Jovanović, P., Spasojević-Tišma, V. D., Delic, N.,& Dronjak, S.. (2011). Differential in Vivo Regulation of Th and Dbh Mrna in Rat Atria By Maprotiline and Fluoxetine. in Archives of Biological Sciences, 63(3), 597-601. https://doi.org/10.2298/ABS1103597S
Spasojević N, Jovanović P, Spasojević-Tišma VD, Delic N, Dronjak S. Differential in Vivo Regulation of Th and Dbh Mrna in Rat Atria By Maprotiline and Fluoxetine. in Archives of Biological Sciences. 2011;63(3):597-601. doi:10.2298/ABS1103597S .
Spasojević, Nataša, Jovanović, Predrag, Spasojević-Tišma, Vera D., Delic, N., Dronjak, Slađana, "Differential in Vivo Regulation of Th and Dbh Mrna in Rat Atria By Maprotiline and Fluoxetine" in Archives of Biological Sciences, 63, no. 3 (2011):597-601, https://doi.org/10.2298/ABS1103597S . .