Gender-related differences in the oxidant state of cells in Fanconi anemia heterozygotes
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Autori
Petrović, SandraLeskovac, Andreja
Kotur-Stevuljevic, Jelena
Joksić, Jelena
Guć-Šćekić, Marija
Vujić, Dragana
Joksić, Gordana
Članak u časopisu
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Fanconi anemia (FA) is a rare cancer-prone genetic disorder characterized by progressive bone marrow failure, chromosomal instability and redox abnormalities. There is much biochemical and genetic data, which strongly suggest that FA cells experience increased oxidative stress. The present study was designed to elucidate if differences in oxidant state exist between control, idiopathic bone marrow failure (idBMF) and FA cells, and to analyze oxidant state of cells in FA heterozygous carriers as well. The results of the present study confirm an in vivo prooxidant state of FA cells and clearly indicate that FA patients can be distinguished from idBMF patients based on the oxidant state of cells. Female carriers of FA mutation also exhibited hallmarks of an in vivo prooxidant state behaving in a similar manner as FA patients. On the other hand, the oxidant state of cells in FA male carriers and idBMF families failed to show any significant difference vs. controls. We demonstrate that the ...altered oxidant state influences susceptibility of cells to apoptosis in both FA patients and female carriers. The results highlight the need for further research of the possible role of mitochondrial inheritance in the pathogenesis of FA.
Ključne reči:
apoptosis / catalase / extracellular superoxide dismutase / Fanconi anemia / oxidative stressIzvor:
Biological Chemistry, 2011, 392, 7, 625-632Finansiranje / projekti:
- Radiosenzitivnost humanog genoma (RS-MESTD-Basic Research (BR or ON)-173046)
DOI: 10.1515/BC.2011.064
ISSN: 1431-6730
PubMed: 21619480
WoS: 000291533300005
Scopus: 2-s2.0-79959441251
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Institucija/grupa
VinčaTY - JOUR AU - Petrović, Sandra AU - Leskovac, Andreja AU - Kotur-Stevuljevic, Jelena AU - Joksić, Jelena AU - Guć-Šćekić, Marija AU - Vujić, Dragana AU - Joksić, Gordana PY - 2011 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4379 AB - Fanconi anemia (FA) is a rare cancer-prone genetic disorder characterized by progressive bone marrow failure, chromosomal instability and redox abnormalities. There is much biochemical and genetic data, which strongly suggest that FA cells experience increased oxidative stress. The present study was designed to elucidate if differences in oxidant state exist between control, idiopathic bone marrow failure (idBMF) and FA cells, and to analyze oxidant state of cells in FA heterozygous carriers as well. The results of the present study confirm an in vivo prooxidant state of FA cells and clearly indicate that FA patients can be distinguished from idBMF patients based on the oxidant state of cells. Female carriers of FA mutation also exhibited hallmarks of an in vivo prooxidant state behaving in a similar manner as FA patients. On the other hand, the oxidant state of cells in FA male carriers and idBMF families failed to show any significant difference vs. controls. We demonstrate that the altered oxidant state influences susceptibility of cells to apoptosis in both FA patients and female carriers. The results highlight the need for further research of the possible role of mitochondrial inheritance in the pathogenesis of FA. T2 - Biological Chemistry T1 - Gender-related differences in the oxidant state of cells in Fanconi anemia heterozygotes VL - 392 IS - 7 SP - 625 EP - 632 DO - 10.1515/BC.2011.064 ER -
@article{ author = "Petrović, Sandra and Leskovac, Andreja and Kotur-Stevuljevic, Jelena and Joksić, Jelena and Guć-Šćekić, Marija and Vujić, Dragana and Joksić, Gordana", year = "2011", abstract = "Fanconi anemia (FA) is a rare cancer-prone genetic disorder characterized by progressive bone marrow failure, chromosomal instability and redox abnormalities. There is much biochemical and genetic data, which strongly suggest that FA cells experience increased oxidative stress. The present study was designed to elucidate if differences in oxidant state exist between control, idiopathic bone marrow failure (idBMF) and FA cells, and to analyze oxidant state of cells in FA heterozygous carriers as well. The results of the present study confirm an in vivo prooxidant state of FA cells and clearly indicate that FA patients can be distinguished from idBMF patients based on the oxidant state of cells. Female carriers of FA mutation also exhibited hallmarks of an in vivo prooxidant state behaving in a similar manner as FA patients. On the other hand, the oxidant state of cells in FA male carriers and idBMF families failed to show any significant difference vs. controls. We demonstrate that the altered oxidant state influences susceptibility of cells to apoptosis in both FA patients and female carriers. The results highlight the need for further research of the possible role of mitochondrial inheritance in the pathogenesis of FA.", journal = "Biological Chemistry", title = "Gender-related differences in the oxidant state of cells in Fanconi anemia heterozygotes", volume = "392", number = "7", pages = "625-632", doi = "10.1515/BC.2011.064" }
Petrović, S., Leskovac, A., Kotur-Stevuljevic, J., Joksić, J., Guć-Šćekić, M., Vujić, D.,& Joksić, G.. (2011). Gender-related differences in the oxidant state of cells in Fanconi anemia heterozygotes. in Biological Chemistry, 392(7), 625-632. https://doi.org/10.1515/BC.2011.064
Petrović S, Leskovac A, Kotur-Stevuljevic J, Joksić J, Guć-Šćekić M, Vujić D, Joksić G. Gender-related differences in the oxidant state of cells in Fanconi anemia heterozygotes. in Biological Chemistry. 2011;392(7):625-632. doi:10.1515/BC.2011.064 .
Petrović, Sandra, Leskovac, Andreja, Kotur-Stevuljevic, Jelena, Joksić, Jelena, Guć-Šćekić, Marija, Vujić, Dragana, Joksić, Gordana, "Gender-related differences in the oxidant state of cells in Fanconi anemia heterozygotes" in Biological Chemistry, 392, no. 7 (2011):625-632, https://doi.org/10.1515/BC.2011.064 . .