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dc.creatorMartinović, Jelena
dc.creatorFilipović, Dragana
dc.date.accessioned2018-03-01T21:46:49Z
dc.date.available2018-03-01T21:46:49Z
dc.date.issued2011
dc.identifier.issn0300-8177 (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/4347
dc.description.abstractExposure to different stressors initiates generation of reactive oxygen species (ROS), which create harmful environment for cellular macromolecules. Superoxide dismutases (SODs) represent the first line of antioxidant defense. Hence, any alternation in their function might be potentially damaging. To better define the role of SODs, we investigated the CuZnSOD activity in cytosolic and the nuclear fraction as well as mitochondrial MnSOD activity in the liver of Wistar male rats after exposure to 2 h of acute immobilization (IM) or cold (4A degrees C) stress, 21 days of chronic social isolation (IS) or their combination (chronic stress followed by acute stress). Serum corticosterone (CORT) was monitored as an indicator of the stress response. Acute IM stress, with elevated CORT level, led to increased hepatic CuZnSOD activity in the nuclear fraction. Chronic isolation stress, where CORT was close to control value, did not change the CuZnSOD activity either in nuclei or in cytosolic fraction, while combined stress IS+Cold led to increased cytosolic CuZnSOD activity. MnSOD activity in mitochondrial fraction was decreased in all treated groups. Data have shown that different stressors have diverse effect on hepatic CuZnSOD and MnSOD activity as well as on serum CORT level. Increased nuclear CuZnSOD activity after acute stress represents physiological response since the named activity protects cells against oxidative stress, while chronic IS stress compromises CuZnSOD function, suggesting an inefficient defense against ROS. Observed decrease of MnSOD activities indicate inadequate elimination of ROS after acute or chronic stress, which is characteristic of the oxidative stress.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173023/RS//
dc.rightsrestrictedAccessen
dc.sourceMolecular and Cellular Biochemistryen
dc.subjectStressen
dc.subjectCuZnSODen
dc.subjectMnSODen
dc.subjectCorticosteroneen
dc.subjectLiveren
dc.titleStress-induced alternations in CuZnSOD and MnSOD activity in cellular compartments of rat liveren
dc.typearticleen
dcterms.abstractМартиновић Јелена; Филиповић Драгана;
dc.citation.volume357
dc.citation.issue1-2
dc.citation.spage143
dc.citation.epage150
dc.identifier.wos000295941500016
dc.identifier.doi10.1007/s11010-011-0884-4
dc.citation.rankM23
dc.identifier.pmid21625958
dc.identifier.scopus2-s2.0-84857393337


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