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dc.creatorTopalović Žukovec, Dijana
dc.creatorŽivković, Lada
dc.creatorCabarkapa, Andrea
dc.creatorDjelic, Ninoslav
dc.creatorBajić, Vladan P.
dc.creatorDekanski, Dragana
dc.creatorSpremo-Potparević, Biljana
dc.date.accessioned2018-03-01T15:58:05Z
dc.date.available2018-03-01T15:58:05Z
dc.date.issued2015
dc.identifier.issn1942-0900 (print)
dc.identifier.issn1942-0994 (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/432
dc.description.abstractThe thyroid hormones change the rate of basal metabolism, modulating the consumption of oxygen and causing production of reactive oxygen species, which leads to the development of oxidative stress and DNA strand breaks. Olive (Olea europaea L.) leaf contains many potentially bioactive compounds, making it one of the most potent natural antioxidants. The objective of this study was to evaluate the genotoxicity of L-thyroxine and to investigate antioxidative and antigenotoxic potential of the standardized oleuropein-rich dry olive leaf extract (DOLE) against hydrogen peroxide and L-thyroxine-induced DNA damage in human peripheral blood leukocytes by using the comet assay. Various concentrations of the extract were tested with both DNA damage inducers, under two different experimental conditions, pretreatment and posttreatment. Results indicate that L-thyroxine exhibited genotoxic effect and that DOLE displayed protective effect against thyroxine-induced genotoxicity. The number of cells with DNA damage, was significantly reduced, in both pretreated and posttreated samples (P LT 0.05). Comparing the beneficial effect of all tested concentrations of DOLE, in both experimental protocols, it appears that extract was more effective in reducing DNA damage in the pretreatment, exhibiting protective role against L-thyroxine effect. This feature of DOLE can be explained by its capacity to act as potent free radical scavenger.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173034/RS//
dc.rightsopenAccessen
dc.sourceOxidative Medicine and Cellular Longevityen
dc.titleDry Olive Leaf Extract Counteracts L-Thyroxine-Induced Genotoxicity in Human Peripheral Blood Leukocytes In Vitroen
dc.typearticleen
dcterms.abstractДекански, Драгана; Бајић Владан П.; Топаловиц, Дијана Зуковец; Дјелиц, Нинослав; Зивковиц, Лада; Цабаркапа, Aндреа; Спремо-Потпаревиц, Биљана;
dc.identifier.wos000350664000001
dc.identifier.doi10.1155/2015/762192
dc.citation.otherArticle Number: 762192
dc.citation.rankM22
dc.identifier.scopus2-s2.0-84924249662
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs//bitstream/id/12747/428.pdf


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