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dc.creatorĐorđević, Jelena D.
dc.creatorĐorđević, Ana D.
dc.creatorAdžić, Miroslav
dc.creatorElakovic, Ivana
dc.creatorMatić, Gordana
dc.creatorRadoičić, Marija B.
dc.date.accessioned2018-03-01T21:45:17Z
dc.date.available2018-03-01T21:45:17Z
dc.date.issued2011
dc.identifier.issn0014-2999 (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/4329
dc.description.abstractSelective serotonin reuptake inhibitors (SSRI) are a treatment of choice for stress related disorders including clinical depression and a range of anxiety-related disorders. In the experimental animals, chronic stress paradigms are considered as a model of depression, and in that context are used for examining the effects of different drug treatments. The present research was designed to investigate the effect of SSRI fluoxetine on antioxidant status and apoptotic signaling in Wistar rat liver, which is a central organ for activation and detoxification of many xenobiotics and reactive oxygen species. We also investigated whether chronic fluoxetine treatment exhibits the same effects in the liver of control animals vs. animals stressed by chronic psychosocial isolation. Our results revealed that fluoxetine downregulated the activity of superoxide dismutases and upregulated the activity of glutathione peroxidase in both rat groups, while elevating glutathione reductase activity and total antioxidant status only in stressed animals. These results suggested that fluoxetine interfered with stress-induced pathways of oxidative defense in the liver. In addition, in both experimental groups, fluoxetine induced several hallmarks of apoptosis in the liver, including a decrease in Bcl-2 expression and increased DNA fragmentation. However, apoptotic alterations were more pronounced in stressed animals, suggesting that stress related oxidative damage could have primed apoptotic effects of fluoxetine. (C) 2011 Elsevier B.V. All rights reserved.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41029/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41009/RS//
dc.rightsrestrictedAccessen
dc.sourceEuropean Journal of Pharmacologyen
dc.subjectLiveren
dc.subjectFluoxetineen
dc.subjectStressen
dc.subjectAntioxidant enzymeen
dc.subjectApoptosisen
dc.titleFluoxetine affects antioxidant system and promotes apoptotic signaling in Wistar rat liveren
dc.typearticleen
dcterms.abstractЕлаковиц, Ивана; Ђорђевић Јелена Д.; Ђорђевић Aна Д; Aджић Мирослав; Матиц, Гордана; Радоичић Марија;
dc.citation.volume659
dc.citation.issue1
dc.citation.spage61
dc.citation.epage66
dc.identifier.wos000291119300009
dc.identifier.doi10.1016/j.ejphar.2011.03.003
dc.citation.rankM22
dc.identifier.pmid21414309
dc.identifier.scopus2-s2.0-79958828800


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