Chronic Hepatitis C, Insulin Resistance and Vascular Disease
Nema prikaza
Autori
Trpković, AndrejaStokić, Edita
Radak, Đorđe J.
Gluvić, Zoran
Haidara, Mohamed A.
Mikhailidis, Dimitri P.
Isenović, Esma R.
Prikaz
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The role of hepatitis C virus (HCV) infection in the development of vascular disease is controversial. Insulin resistance (IR) is a recognized risk factor for cardiovascular disease (CVD) and is associated with chronic hepatitis C (CHC). Thus, IR may promote atherosclerosis and vascular disease in CHC patients. HCV-associated IR may also cause hepatic steatosis and resistance to antiviral treatment. In addition, HCV may contribute a direct, proatherogenetic action on the vascular wall. This review considers the impact of IR on interferon-based therapy of HCV infection and the role of insulin-sensitizing agents on the response to antiviral treatment and prevention of IR complications, including CVD.
Ključne reči:
Hepatitis C / insulin resistance / interferon-alpha / vascular diseaseIzvor:
Current Pharmaceutical Design, 2010, 16, 34, 3823-3829Finansiranje / projekti:
- Hormonska regulacija ekspresije i aktivnosti azot oksid sintaze i natrijum-kalijumove pumpe u eksperimentalnim modelima insulinske rezistencije, dijabetesa i kardiovaskularnih poremećaja (RS-MESTD-Basic Research (BR or ON)-173033)
DOI: 10.2174/138161210794455067
ISSN: 1381-6128; 1873-4286
PubMed: 21128893
WoS: 000286877500006
Scopus: 2-s2.0-79551635641
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Trpković, Andreja AU - Stokić, Edita AU - Radak, Đorđe J. AU - Gluvić, Zoran AU - Haidara, Mohamed A. AU - Mikhailidis, Dimitri P. AU - Isenović, Esma R. PY - 2010 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4208 AB - The role of hepatitis C virus (HCV) infection in the development of vascular disease is controversial. Insulin resistance (IR) is a recognized risk factor for cardiovascular disease (CVD) and is associated with chronic hepatitis C (CHC). Thus, IR may promote atherosclerosis and vascular disease in CHC patients. HCV-associated IR may also cause hepatic steatosis and resistance to antiviral treatment. In addition, HCV may contribute a direct, proatherogenetic action on the vascular wall. This review considers the impact of IR on interferon-based therapy of HCV infection and the role of insulin-sensitizing agents on the response to antiviral treatment and prevention of IR complications, including CVD. T2 - Current Pharmaceutical Design T1 - Chronic Hepatitis C, Insulin Resistance and Vascular Disease VL - 16 IS - 34 SP - 3823 EP - 3829 DO - 10.2174/138161210794455067 ER -
@article{ author = "Trpković, Andreja and Stokić, Edita and Radak, Đorđe J. and Gluvić, Zoran and Haidara, Mohamed A. and Mikhailidis, Dimitri P. and Isenović, Esma R.", year = "2010", abstract = "The role of hepatitis C virus (HCV) infection in the development of vascular disease is controversial. Insulin resistance (IR) is a recognized risk factor for cardiovascular disease (CVD) and is associated with chronic hepatitis C (CHC). Thus, IR may promote atherosclerosis and vascular disease in CHC patients. HCV-associated IR may also cause hepatic steatosis and resistance to antiviral treatment. In addition, HCV may contribute a direct, proatherogenetic action on the vascular wall. This review considers the impact of IR on interferon-based therapy of HCV infection and the role of insulin-sensitizing agents on the response to antiviral treatment and prevention of IR complications, including CVD.", journal = "Current Pharmaceutical Design", title = "Chronic Hepatitis C, Insulin Resistance and Vascular Disease", volume = "16", number = "34", pages = "3823-3829", doi = "10.2174/138161210794455067" }
Trpković, A., Stokić, E., Radak, Đ. J., Gluvić, Z., Haidara, M. A., Mikhailidis, D. P.,& Isenović, E. R.. (2010). Chronic Hepatitis C, Insulin Resistance and Vascular Disease. in Current Pharmaceutical Design, 16(34), 3823-3829. https://doi.org/10.2174/138161210794455067
Trpković A, Stokić E, Radak ĐJ, Gluvić Z, Haidara MA, Mikhailidis DP, Isenović ER. Chronic Hepatitis C, Insulin Resistance and Vascular Disease. in Current Pharmaceutical Design. 2010;16(34):3823-3829. doi:10.2174/138161210794455067 .
Trpković, Andreja, Stokić, Edita, Radak, Đorđe J., Gluvić, Zoran, Haidara, Mohamed A., Mikhailidis, Dimitri P., Isenović, Esma R., "Chronic Hepatitis C, Insulin Resistance and Vascular Disease" in Current Pharmaceutical Design, 16, no. 34 (2010):3823-3829, https://doi.org/10.2174/138161210794455067 . .