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Improving attrition rates in Ebola virus drug discovery
(Expert Opinion on Drug Discovery, 2015)
Introduction: The Ebola 2014/2015 outbreak has had devastating effects on the people living in West Africa. The spread of the disease in endemic countries and the potential introduction of sporadic cases in other continents ...
DNA microarrays - A new dimension in molecular oncology
(Jugoslovenska Medicinska Biohemija, 2001)
DNA microarrays or gene chips are methods of performing an enormous number of parallel DNA hybridization experiments. Technically, this approach relies on the orderly attachment of a gene probes on solid surface (the array) ...
Hormonal Regulation of Nitric Oxide (NO) in Cardio-metabolic Diseases
(Current Pharmaceutical Design, 2017)
Background: Nitric oxide (NO) is a potential biochemical, cardio-metabolic risk marker. The production of NO is catalyzed by different isoforms of enzymes, NO synthases (NOS). An altered NO level is associated with obesity, ...
Regulation of Na+/K+-ATPase by Estradiol and IGF-1 in Cardio-Metabolic Diseases
(Current Pharmaceutical Design, 2017)
Background: The sodium/potassium- adenosine- triphosphatase (Na+/K+-ATPase) is an important mediator in vasculature tone and contractility, and its abnormal regulation has been implicated in many diseases such as obesity, ...
Modulation of Antioxidant Enzyme Activities by Sexual Steroid Hormones
(Physiological Research, 2008)
Taking into consideration the biological importance of interaction between antioxidant defense (AD) enzymes and sexual steroid hormones it was deemed important to compare our recent achievements in the field with the state ...
Application of the EIIP/ISM bioinformatics concept in development of new drugs
(Current Medicinal Chemistry, 2007)
The development of a new therapeutic drug is a complex, lengthy and expensive process. On average, only one out of 10,000 - 30,000 originally synthesized compounds will clear all the hurdles on the way to becoming a ...
Determination of glass temperature of polymers by inverse gas chromatography
(Journal of Chromatography A, 2008)
Inverse gas chromatography (IGC) is an attractive technique for polymer characterization due to possible simultaneous determination of various physicochemical properties of polymer systems merely from retention times of ...
Recombination property of the HIV-1 gp120 gene
(International Reviews of Immunology, 2004)
Using a chimeric primer consisting of the nucleotide sequence derived from the HIV-1 envelope gene coding for the second conserved region of gp120, and the highly conserved sequence derived from the human immunoglobulin ...
Regulation of antioxidant enzyme activities in female rat brain by ovarian steroids
(Periodicum Biologorum, 2008)
The sex steroids produce their effects by acting on numerous target tissues and organs, such as the reproductive organs, bone tissue and cartilage, peripheral blood vessels as well as the central nervous system (CNS). In ...
Mechanism of Na+/K+-Atpase and Mg2+-Atpase Inhibition By Metal Ions and Complexes
(Hemijska industrija, 2009)
The aim of the study was to give an overview of the mechanism of inhibition of Na+/K+-ATPase and Mg2+-ATPase activity, the enzymes playing a key role in the active transport of monovalent cations (Na+ and K+) across the ...