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Now showing items 1581-1590 of 1608
Developmental Increase in Ecto-5-Nucleotidase Activity Overlaps with Appearance of Two Immunologically Distinct Enzyme Isoforms in Rat Hippocampal Synaptic Plasma Membranes
(Journal of Molecular Neuroscience, 2014)
Ecto-5-nucleotidase (e-5NT), a glycosylphosphatidylinositol-linked membrane protein, catalyzes a conversion of AMP to adenosine, which influences nearly every aspect of brain physiology, including embryonic and postnatal ...
Upregulation of Nucleoside Triphosphate Diphosphohydrolase-1 and Ecto-5-Nucleotidase in Rat Hippocampus after Repeated Low-Dose Dexamethasone Administration
(Journal of Molecular Neuroscience, 2015)
Although dexamethasone (DEX), a synthetic glucocorticoid receptor (GR) analog with profound effects on energy metabolism, immune system, and hypothalamic-pituitary-adrenal axis, is widely used therapeutically, its impact ...
Time-Related Sex Diffrences in Cerebral Hypoperfusion-Induced Brain Injury
(Archives of biological sciences, 2014)
Although the model of cerebral hypoperfusion in rats has been a matter of many investigations over the years, the exact intracellular and biochemical mechanisms that lead to neuron loss and memory decline have not been ...
Time Course of Cerebral Hypoperfusion-Induced Neurodegenerative Changes in the Cortex of Male and Female Rats
(Folia Biologica, 2014)
To study time-dependent and gender-specific intracellular and biochemical mechanisms that lead to neurodegeneration due to moderate but persistent reduction of cerebral blood flow, adult male and female Wistar rats were ...
Regional and sex-related differences in modulating effects of female sex steroids on ecto-5-nucleotidase expression in the rat cerebral cortex and hippocampus
(General and Comparative Endocrinology, 2016)
Ecto-5-nucleotidase (eN), a membrane rate-limiting enzyme of the purine catabolic pathway, catalyzes the conversion of AMP to adenosine involved in the regulation of many brain physiological and pathological processes. ...
Repeated Estradiol Treatment Attenuates Chronic Cerebral Hypoperfusion-Induced Neurodegeneration in Rat Hippocampus
(Cellular and Molecular Neurobiology, 2016)
Although a substantial number of pre-clinical and experimental studies have investigated effects of 17 beta-estradiol, its precise molecular mechanism of action in the early state of chronic cerebral hypoperfusion remains ...
Expression of ecto-nucleoside triphosphate diphosphohydrolase3 (NTPDase3) in the female rat brain during postnatal development
(Journal of Chemical Neuroanatomy, 2016)
Nucleoside triphosphate diphosphohydrolase3 (NTPDase3) is membrane-bound ecto-enzyme which hydrolyzes extracellular ATP, thus modulating the function of purinergic receptors and the pattern of purinergic signaling. Here ...
First results studying the transmutation of (129)I, (237)Np, (238)Pu, and (239)Pu in the irradiation of an extended (nat)U/Pb-assembly with 2.52 GeV deuterons
(Journal of Radioanalytical and Nuclear Chemistry, 2009)
An extended U/Pb-assembly was irradiated with an extracted beam of 2.52 GeV deuterons from the Nuclotron accelerator of the Laboratory of High Energies within the JINR in Dubna, Russia. The lay-out of this experiment and ...
The role of G protein coupled receptor kinases in neurocardiovascular pathophysiology
(Archives of Medical Science, 2012)
In coronary artery disease the G protein related kinases (GRKs) play a role in desensitization of beta-adrenoreceptors (AR) after coronary occlusion. Targeted deletion and lowering of cardiac myocyte GRK-2 decreases the ...
RR interval-respiratory signal waveform modeling in human slow paced and spontaneous breathing
(Respiratory Physiology and Neurobiology, 2014)
Our aim was to model the dependence of respiratory sinus arrhythmia (RSA) on the respiratory waveform and to elucidate underlying mechanisms of cardiorespiratory coupling. In 30 subjects, RR interval and respiratory signal ...