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Cytogenetic effects of 8-Cl-cAMP on human and animal chromosomes
(Journal of BUON, 2009)
Purpose: To assess the cytogenetic effects in vitro and in vivo of a non-cytotoxic antitumor agent with biomodulator activity, 8-chloro-3, 5 cyclic adenosine monophosphate (8-Cl-cAMP). Materials and methods: Cytogenetic ...
The combination of gamma ionizing radiation and 8-Cl-cAMP induces synergistic cell growth inhibition and induction of apoptosis in human prostate cancer cells
(Investigational New Drugs, 2008)
The antiproliferative and cytotoxic potential of the nucleotide analog 8-Cl-cAMP was tested in PC-3 and DU145 metastatic human prostate cancer cells. The drug was examined as the only therapeutic agent and in combination ...