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Toxicity of pristine versus functionalized fullerenes: mechanisms of cell damage and the role of oxidative stress
(Archives of Toxicology, 2012)
The fullerene C-60, due to the physicochemical properties of its spherical cage-like molecule build exclusively from carbon atoms, is able to both scavenge and generate reactive oxygen species. While this unique dual ...
Insulin, Thrombin, ERK1/2 Kinase and Vascular Smooth Muscle Cells Proliferation
(Current Pharmaceutical Design, 2010)
Vascular smooth muscle cells (VSMC) respond to arterial wall injury by intimal proliferation and play a key role in atherogenesis by proliferating and migrating excessively in response to repeated injury, such as hypertension ...
Application of the EIIP/ISM bioinformatics concept in development of new drugs
(Current Medicinal Chemistry, 2007)
The development of a new therapeutic drug is a complex, lengthy and expensive process. On average, only one out of 10,000 - 30,000 originally synthesized compounds will clear all the hurdles on the way to becoming a ...
Guidelines for the use and interpretation of assays for monitoring autophagy
(Autophagy, 2012)
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base ...
Diamond synthesized at low pressure
(Chemistry and Physics of Carbon, 2004)
Sol-gel synthesis and characterization of iron doped mullite
(Journal of Alloys and Compounds, 2014)
Amorphous powders of iron doped 3:2 mullite (3Al(2)O(3)center dot 2SiO(2)) were prepared by sol-gel combustion process using ethanol-water solutions of Al(III) nitrate, Fe(III) nitrate, TEOS and urea. Compositions up to ...
Biomedical potential of the reactive oxygen species generation and quenching by fullerenes (C-60)
(Biomaterials, 2008)
Fullerene (C-60), a third carbon allotrope, is a classical engineered material with the potential application in biomedicine. One of the biologically most relevant features of C-60 is the ability to quench various free ...
The challenge of merging food safety diagnostic needs with quantitative PCR platforms
(Trends in Food Science and Technology, 2011)
The field of food microbiology and safety has experienced an exciting time in the last 10 years. New methods have been introduced to assess safety of foods by targeting pathogenic microorganisms without the need for ...
Determination of thermal conductivity of baled agricultural biomass
(Elsevier, 2016)
Modeling of transport phenomena in materials with porous bed features requires thermophysical properties, such as porosity, permeability and thermal conductivity be known. The paper presents experimental data obtained in ...
Involvement of the ADAM 12 in Thrombin-Induced Rats VSMCs Proliferation
(Current Medicinal Chemistry, 2011)
Cardiovascular disease is the largest single cause of mortality and its major underlying pathology is atherosclerosis. The proliferation of vascular smooth muscle cells (VSMCs) is a key event in the pathogenesis of the ...