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Changes in cardiac Na+/K+-ATPase expression and activity in female rats fed a high-fat diet
(Molecular and Cellular Biochemistry, 2017)
The aim of this study was to investigate whether the presence of endogenous estradiol alters the effects of a high-fat (HF) diet on activity/expression of the cardiac Na+/K+-ATPase, via PI3K/IRS and RhoA/ROCK signalling ...
Interaction of some pd(II) complexes with Na+/K+-ATPase: Inhibition, kinetics, prevention and recovery
(Journal of Enzyme Inhibition and Medicinal Chemistry, 2006)
The aim of this work was to investigate the influence of [PdCl4](2-), [PdCl(dien)](+) and [PdCl(Me(4)dien)](+) complexes on Na+/K+-ATPase activity. The dose-dependent inhibition curves were obtained in all cases. IC50 ...
Regulation of hepatic Na+/K+-ATPase in obese female and male rats: involvement of ERK1/2, AMPK, and Rho/ROCK
(Molecular and Cellular Biochemistry, 2018)
In this study, we assessed whether the disturbed regulation of sodium/potassium-adenosine-triphosphatase (Na+/K+-ATPase) occurs as a consequence of obesity-induced IR in sex-specific manner. We also assessed whether ...
Prevention and recovery of CuSO4-induced inhibition of Na+/K+-ATPase and Mg2+-ATPase in rat brain synaptosomes by EDTA
(Toxicology Letters, 1999)
Enzymatic activities of Na+/K+-ATPase and Mg2+-ATPase from rat brain synaptic plasma membrane were studied in the absence and presence of EDTA. The aim of the study was to examine the ability of this strong chelator to ...
The activity of erythrocyte and brain Na+/K+ and Mg2+-ATPases in rats subjected to acute homocysteine and homocysteine thiolactone administration
(Molecular and Cellular Biochemistry, 2009)
Hyperhomocysteinemia is associated with various pathologies including cardiovascular disease, stroke, and cognitive dysfunctions. Systemic administration of homocysteine can trigger seizures in animals, and patients with ...
Effects of digoxin and gitoxin on the enzymatic activity and kinetic parameters of Na+/K+-ATPase
(Journal of Enzyme Inhibition and Medicinal Chemistry, 2004)
Inhibition of Na+/K+-ATPase activity from human erythrocyte membranes and commercial porcine cerebral cortex by in vitro single and simultaneous exposure to digoxin and gitoxin was investigated to elucidate the difference ...
The influence of potassium ion (K+) on digoxin-induced inhibition of porcine cerebral cortex Na+/K+-ATPase
(Journal of Enzyme Inhibition and Medicinal Chemistry, 2006)
The in vitro influence of potassium ion modulations, in the concentration range 2mM - 500mM, on digoxin-induced inhibition of porcine cerebral cortex Na+/K+-ATPase activity was studied. The response of enzymatic activity ...
The effect of subchronic supplementation with folic acid and L-arginine on homocysteine-induced seizures
(Canadian Journal of Physiology and Pharmacology, 2016)
The aim of the present study was to examine the effect of subchronic co-administration of folic acid (F) and L-arginine (A) on behavioural and electroencephalographic (EEG) characteristics of DL homocysteine thiolactone ...