Now showing items 1-6 of 6
Distinct cytotoxic mechanisms of pristine versus hydroxylated fullerene
(Toxicological Sciences, 2006)
The mechanisms underlying the cytotoxic action of pure fullerene suspension (nano-C-60) and water-soluble polyhydroxylated fullerene [C-60(OH)(n)] were investigated. Crystal violet assay for cell viability demonstrated ...
Modulation of tumor necrosis factor-mediated cell death by fullerenes
(Pharmaceutical Research, 2008)
Purpose. The fullerene (C-60/C-70 mixture-C-60/70) nanocrystalline suspension prepared by solvent exchange method using tetrahydrofyran (THF/nC(60/70)) and polyhydroxylated C-60/70 [C-60/70(OH)(n)] were compared for their ...
Dual antiglioma action of metformin: cell cycle arrest and mitochondria-dependent apoptosis
(Cellular and Molecular Life Sciences / CMLS, 2007)
The present study reports for the first time a dual antiglioma effect of the well-known antidiabetic drug metformin. In low-density cultures of the C6 rat glioma cell line, metformin blocked the cell cycle progression in ...
The combination of gamma ionizing radiation and 8-Cl-cAMP induces synergistic cell growth inhibition and induction of apoptosis in human prostate cancer cells
(Investigational New Drugs, 2008)
The antiproliferative and cytotoxic potential of the nucleotide analog 8-Cl-cAMP was tested in PC-3 and DU145 metastatic human prostate cancer cells. The drug was examined as the only therapeutic agent and in combination ...
Inhibition of B16 mouse melanoma cell growth and induction of apoptotic cell death with 8-chloroadenosine-3 5,-monophosphate and tiazofurin
(Annals of the New York Academy of Sciences, 2004)
Novel antineoplastic agents, 8-chloroadenosine 3,5-monophosphate (8-Cl-cAMP) and tiazofurin (TR), have been shown to be effective against different malignant cells. Through specific mechanisms of action they modulate the ...
Response of a human melanoma cell line to low and high ionizing radiation
(Annals of the New York Academy of Sciences, 2007)
Effects of single irradiation with gamma rays and protons on human HTB140 melanoma cell growth were compared. Exponentially growing cells were irradiated close to the Bragg peak maximum of the unmodulated 62 MeV protons, ...