In vitro comparison of the photothermal anticancer activity of graphene nanoparticles and carbon nanotubes
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Marković, Zoran M.Harhaji-Trajković, Ljubica M.
Todorović-Marković, Biljana
Kepić, Dejan P.
Arsikin, Katarina M.
Jovanović, Svetlana P.
Pantovic, Aleksandar C.
Dramićanin, Miroslav
Trajković, Vladimir S.
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The present study compared the photothermal anticancer activity of near-infrared (NIR)-excited graphene nanoparticles and carbon nanotubes (CNT). Despite lower NIR-absorbing capacity, suspension of polyvinylpyrrolidone-coated graphene sheets exposed to NIR radiation (808 nm, 2 W/cm(2)) generated more heat than DNA or sodium dodecylbenzenesulfonate-solubilized single-wall CNT under the same conditions. Accordingly, graphene nanoparticles performed significantly better than CNT in inducing photothermal death of U251 human glioma cells in vitro. The superior photothermal sensitivity of graphene sheets could be largely explained by their better dispersivity, which has been supported by a simple calculation taking into account thermodynamic, optical and geometrical properties of the two type of carbon nanoparticles. The mechanisms of graphene-mediated photothermal killing of cancer cells apparently involved oxidative stress and mitochondrial membrane depolarization resulting in mixed apopto...tic and necrotic cell death characterized by caspase activation/DNA fragmentation and cell membrane damage, respectively. (c) 2010 Elsevier Ltd. All rights reserved.
Keywords:
Graphene / Carbon nanotubes / Cancer / Hyperthermia / ApoptosisSource:
Biomaterials, 2011, 32, 4, 1121-1129
DOI: 10.1016/j.biomaterials.2010.10.030
ISSN: 0142-9612
PubMed: 21071083
WoS: 000285675200019
Scopus: 2-s2.0-78649443626
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VinčaTY - JOUR AU - Marković, Zoran M. AU - Harhaji-Trajković, Ljubica M. AU - Todorović-Marković, Biljana AU - Kepić, Dejan P. AU - Arsikin, Katarina M. AU - Jovanović, Svetlana P. AU - Pantovic, Aleksandar C. AU - Dramićanin, Miroslav AU - Trajković, Vladimir S. PY - 2011 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4179 AB - The present study compared the photothermal anticancer activity of near-infrared (NIR)-excited graphene nanoparticles and carbon nanotubes (CNT). Despite lower NIR-absorbing capacity, suspension of polyvinylpyrrolidone-coated graphene sheets exposed to NIR radiation (808 nm, 2 W/cm(2)) generated more heat than DNA or sodium dodecylbenzenesulfonate-solubilized single-wall CNT under the same conditions. Accordingly, graphene nanoparticles performed significantly better than CNT in inducing photothermal death of U251 human glioma cells in vitro. The superior photothermal sensitivity of graphene sheets could be largely explained by their better dispersivity, which has been supported by a simple calculation taking into account thermodynamic, optical and geometrical properties of the two type of carbon nanoparticles. The mechanisms of graphene-mediated photothermal killing of cancer cells apparently involved oxidative stress and mitochondrial membrane depolarization resulting in mixed apoptotic and necrotic cell death characterized by caspase activation/DNA fragmentation and cell membrane damage, respectively. (c) 2010 Elsevier Ltd. All rights reserved. T2 - Biomaterials T1 - In vitro comparison of the photothermal anticancer activity of graphene nanoparticles and carbon nanotubes VL - 32 IS - 4 SP - 1121 EP - 1129 DO - 10.1016/j.biomaterials.2010.10.030 ER -
@article{ author = "Marković, Zoran M. and Harhaji-Trajković, Ljubica M. and Todorović-Marković, Biljana and Kepić, Dejan P. and Arsikin, Katarina M. and Jovanović, Svetlana P. and Pantovic, Aleksandar C. and Dramićanin, Miroslav and Trajković, Vladimir S.", year = "2011", abstract = "The present study compared the photothermal anticancer activity of near-infrared (NIR)-excited graphene nanoparticles and carbon nanotubes (CNT). Despite lower NIR-absorbing capacity, suspension of polyvinylpyrrolidone-coated graphene sheets exposed to NIR radiation (808 nm, 2 W/cm(2)) generated more heat than DNA or sodium dodecylbenzenesulfonate-solubilized single-wall CNT under the same conditions. Accordingly, graphene nanoparticles performed significantly better than CNT in inducing photothermal death of U251 human glioma cells in vitro. The superior photothermal sensitivity of graphene sheets could be largely explained by their better dispersivity, which has been supported by a simple calculation taking into account thermodynamic, optical and geometrical properties of the two type of carbon nanoparticles. The mechanisms of graphene-mediated photothermal killing of cancer cells apparently involved oxidative stress and mitochondrial membrane depolarization resulting in mixed apoptotic and necrotic cell death characterized by caspase activation/DNA fragmentation and cell membrane damage, respectively. (c) 2010 Elsevier Ltd. All rights reserved.", journal = "Biomaterials", title = "In vitro comparison of the photothermal anticancer activity of graphene nanoparticles and carbon nanotubes", volume = "32", number = "4", pages = "1121-1129", doi = "10.1016/j.biomaterials.2010.10.030" }
Marković, Z. M., Harhaji-Trajković, L. M., Todorović-Marković, B., Kepić, D. P., Arsikin, K. M., Jovanović, S. P., Pantovic, A. C., Dramićanin, M.,& Trajković, V. S.. (2011). In vitro comparison of the photothermal anticancer activity of graphene nanoparticles and carbon nanotubes. in Biomaterials, 32(4), 1121-1129. https://doi.org/10.1016/j.biomaterials.2010.10.030
Marković ZM, Harhaji-Trajković LM, Todorović-Marković B, Kepić DP, Arsikin KM, Jovanović SP, Pantovic AC, Dramićanin M, Trajković VS. In vitro comparison of the photothermal anticancer activity of graphene nanoparticles and carbon nanotubes. in Biomaterials. 2011;32(4):1121-1129. doi:10.1016/j.biomaterials.2010.10.030 .
Marković, Zoran M., Harhaji-Trajković, Ljubica M., Todorović-Marković, Biljana, Kepić, Dejan P., Arsikin, Katarina M., Jovanović, Svetlana P., Pantovic, Aleksandar C., Dramićanin, Miroslav, Trajković, Vladimir S., "In vitro comparison of the photothermal anticancer activity of graphene nanoparticles and carbon nanotubes" in Biomaterials, 32, no. 4 (2011):1121-1129, https://doi.org/10.1016/j.biomaterials.2010.10.030 . .