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Oxidative stress-mediated hemolytic activity of solvent exchange-prepared fullerene (C-60) nanoparticles
dc.creator | Trpković, Andreja | |
dc.creator | Todorović-Marković, Biljana | |
dc.creator | Kleut, Duška | |
dc.creator | Misirkić, Maja | |
dc.creator | Janjetović, Kristina D. | |
dc.creator | Vucicevic, Ljubica | |
dc.creator | Pantovic, Aleksandar | |
dc.creator | Jovanović, Svetlana P. | |
dc.creator | Dramićanin, Miroslav | |
dc.creator | Marković, Zoran M. | |
dc.creator | Trajković, Vladimir S. | |
dc.date.accessioned | 2018-03-01T21:21:28Z | |
dc.date.available | 2018-03-01T21:21:28Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 0957-4484 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/4093 | |
dc.description.abstract | The present study investigated the hemolytic properties of fullerene (C-60) nanoparticles prepared by solvent exchange using tetrahydrofuran (nC(60)THF), or by mechanochemically assisted complexation with macrocyclic oligosaccharide gamma-cyclodextrin (nC(60)CDX) or the copolymer ethylene vinyl acetate-ethylene vinyl versatate (nC(60)EVA-EVV). The spectrophotometrical analysis of hemoglobin release revealed that only nC(60)THF, but not nC(60)CDX or nC(60)EVA-EVV, was able to cause lysis of human erythrocytes in a dose-and time-dependent manner. Atomic force microscopy revealed that nC(60)THF-mediated hemolysis was preceded by erythrocyte shrinkage and increase in cell surface roughness. A flow cytometric analysis confirmed a decrease in erythrocyte size and demonstrated a significant increase in reactive oxygen species production in red blood cells exposed to nC(60)THF. The nC(60)THF-triggered hemolytic activity was efficiently reduced by the antioxidants N-acetylcysteine and butylated hydroxyanisole, as well as by serum albumin, the most abundant protein in human blood plasma. These data indicate that nC(60)THF can cause serum albumin-preventable hemolysis through oxidative stress-mediated damage of the erythrocyte membrane. | en |
dc.relation | Ministry of Science and Technological Development of the Republic of Serbia [145073] | |
dc.rights | restrictedAccess | en |
dc.source | Nanotechnology | en |
dc.title | Oxidative stress-mediated hemolytic activity of solvent exchange-prepared fullerene (C-60) nanoparticles | en |
dc.type | article | en |
dcterms.abstract | Трпковиц, Aндреја; Мисиркиц, Маја; Пантовиц, Aлександар; Јовановиц, Светлана; Трајковиц, Владимир; Тодоровић-Марковић Биљана; Клеут Душка; Јањетовиц, Кристина; Вуцицевиц, Љубица; Драмићанин Мирослав; Марковић Зоран; | |
dc.citation.volume | 21 | |
dc.citation.issue | 37 | |
dc.identifier.wos | 000281398600002 | |
dc.identifier.doi | 10.1088/0957-4484/21/37/375102 | |
dc.citation.other | Article Number: 375102 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 20724776 | |
dc.identifier.scopus | 2-s2.0-77958594837 |
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