Non-Classical Therapeutic Approach in the Treatment of Alzheimers Disease: A Mini Review
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Bajić, Vladan P.
Spremo-Potparević, Biljana

Živković, Lada
Sudar, Emina

Zafirović, Sonja

Obradović, Milan M.

Isenović, Esma R.

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Alzheimers disease (AD) is a multi factorial disease, related to the loss of neurons and synapses in cerebral cortex and subcortical structures, leading to degenerative changes and atrophy. Despite abundance of facts related to AD and its pathology, the only drugs used in the prevention and treatment are those from the cholinesterase inhibitors group. However, there is growing evidence that a non-classical therapeutic approach in the treatment of AD has beneficial effects. In this review we summarized recent literature data related to the non-classical drugs for the treatment of AD predominantly used in clinical testing, such as amyloid aggregation inhibitors, beta-sheet breakers, antioxidants, estrogens and immunotherapeutics.
Keywords:
Amyloid aggregation inhibitors / antioxidants / beta-sheet breakers / estrogens / immunotherapeutic Abeta / neurode-generationSource:
Letters in Drug Design and Discovery, 2015, 12, 2, 158-164Projects:
- Hormonal regulation of expression and activity of the nitric oxide synthase and sodium-potassium pump in experimental models of insulin resistance, diabetes and cardiovascular disorders (RS-173033)
- Cell Cycle Aberrations and the Impact of Oxidative Stress in Neurodegenerative Processes and Malignant Transformation of the Cell (RS-173034)