Show simple item record

dc.creatorTomic, Simonida Lj
dc.creatorMićić, Maja M.
dc.creatorKrezovic, Bojana D.
dc.creatorDobic, Sava N.
dc.creatorSuljovrujić, Edin H.
dc.creatorFilipović, Jovanka M.
dc.date.accessioned2018-03-01T21:10:40Z
dc.date.available2018-03-01T21:10:40Z
dc.date.issued2009
dc.identifier.issn0367-598X (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/3967
dc.description.abstractpH and temperature sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their morphology was examined by scanning electron microscopy (SEM). The morphology and mechanical properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/19027/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/141013/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145072/RS//
dc.rightsopenAccessen
dc.sourceHemijska industrijaen
dc.subjectHydrogelsen
dc.subjectRadiationen
dc.subject2-Hydroxyethyl methacrylateen
dc.subjectItaconic aciden
dc.subjectMechanical propertiesen
dc.subjectSmart hydrogelsen
dc.subjectBiocompatibilityen
dc.subjectMicrobe penetrationen
dc.titleSmart Hydrogels Based on Itaconic Acid for Biomedical Applicationen
dc.typearticleen
dcterms.abstractКрезовиц, Бојана Д.; Добиц, Сава Н.; Мициц, Маја М.; Филиповиц, Јованка М.; Томиц, Симонида Љ; Шуљоврујић Един Х.;
dc.citation.volume63
dc.citation.issue6
dc.citation.spage603
dc.citation.epage610
dc.identifier.wos000276140700002
dc.identifier.doi10.2298/HEMIND0906603T
dc.citation.rankM23
dc.identifier.scopus2-s2.0-77952909341
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs//bitstream/id/12616/3963.pdf


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record