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Thrombocytopenia in Patients With Chronic Hepatitis C: A Possible Role of HCV on Platelet Progenitor Cell Maturation
dc.creator | El Barbary, Magdy A. | |
dc.creator | Saad, Alaa Eldin M. | |
dc.creator | Attia, Fadia M. | |
dc.creator | Mandour, Magda I. | |
dc.creator | Haidara, Mohamed A. | |
dc.creator | Dallak, Mohammad M. | |
dc.creator | Isenović, Esma R. | |
dc.date.accessioned | 2018-03-01T21:07:40Z | |
dc.date.available | 2018-03-01T21:07:40Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 0003-3197 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/3932 | |
dc.description.abstract | A total of 30 patients with chronic hepatitis C (HCV) thrombocytopenia (TP) and 20 healthy controls were studied. Both groups were subjected to complete medical history, clinical examination in addition to assessment of hepatitis markers: level of thrombopoietin (Tpo), Geimsa-stained bone marrow smears, and in vitro short-term megakaryocytic progenitors culture (CFU-MK). Serum Tpo level was significantly elevated in patients with TP HCV. Short-term CFU-MK showed an evident depression in the colony-forming unit-megakaryocyte (CFU-meg). There is a positive correlation between the number of CFU-meg and the platelet count and between serum Tpo level and prothrombin time, transaminase, albumin, and the Child Pugh score of liver disease; a negative correlation between serum Tpo level and the number of CFU-meg and between serum Tpo level and the platelet count. Thus, the level of Tpo could be an indicator of intact functional response of the hepatocytes. | en |
dc.relation | Ministry of Science, Republic of Serbia [143030] | |
dc.rights | restrictedAccess | en |
dc.source | Angiology | en |
dc.subject | short-term megakaryocytic progenitors culture (CFU-MK) | en |
dc.subject | thrombopoietin | en |
dc.subject | hepatitis C | en |
dc.subject | thrombocytopenia | en |
dc.title | Thrombocytopenia in Patients With Chronic Hepatitis C: A Possible Role of HCV on Platelet Progenitor Cell Maturation | en |
dc.type | article | en |
dcterms.abstract | Исеновић Есма; Ел Барбарy, Магдy A.; Саад, Aлаа Елдин М.; Aттиа, Фадиа М.; Мандоур, Магда И.; Хаидара, Мохамед A.; Даллак, Мохаммад М.; | |
dc.citation.volume | 61 | |
dc.citation.issue | 3 | |
dc.citation.spage | 304 | |
dc.citation.epage | 313 | |
dc.identifier.wos | 000275737700013 | |
dc.identifier.doi | 10.1177/0003319709343178 | |
dc.citation.rank | M23 | |
dc.identifier.pmid | 19689996 | |
dc.identifier.scopus | 2-s2.0-77949900771 |
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