Thrombocytopenia in Patients With Chronic Hepatitis C: A Possible Role of HCV on Platelet Progenitor Cell Maturation
AuthorsEl Barbary, Magdy A.
Saad, Alaa Eldin M.
Attia, Fadia M.
Mandour, Magda I.
Haidara, Mohamed A.
Dallak, Mohammad M.
Isenović, Esma R.
MetadataShow full item record
A total of 30 patients with chronic hepatitis C (HCV) thrombocytopenia (TP) and 20 healthy controls were studied. Both groups were subjected to complete medical history, clinical examination in addition to assessment of hepatitis markers: level of thrombopoietin (Tpo), Geimsa-stained bone marrow smears, and in vitro short-term megakaryocytic progenitors culture (CFU-MK). Serum Tpo level was significantly elevated in patients with TP HCV. Short-term CFU-MK showed an evident depression in the colony-forming unit-megakaryocyte (CFU-meg). There is a positive correlation between the number of CFU-meg and the platelet count and between serum Tpo level and prothrombin time, transaminase, albumin, and the Child Pugh score of liver disease; a negative correlation between serum Tpo level and the number of CFU-meg and between serum Tpo level and the platelet count. Thus, the level of Tpo could be an indicator of intact functional response of the hepatocytes.
Keywords:short-term megakaryocytic progenitors culture (CFU-MK) / thrombopoietin / hepatitis C / thrombocytopenia
Source:Angiology, 2010, 61, 3, 304-313
- Ministry of Science, Republic of Serbia