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dc.creatorJovanović-Ćupić, Snežana P.
dc.creatorSimonovic-Babic, Jasmina
dc.creatorBlagojevic, Jelena
dc.creatorBožić, Milena
dc.creatorJešić, Rada
dc.creatorNozic, D.
dc.creatorStamenković, Gorana
dc.date.accessioned2018-03-01T20:52:11Z
dc.date.available2018-03-01T20:52:11Z
dc.date.issued2009
dc.identifier.issn0354-4664 (print)
dc.identifier.issn1821-4339 (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/3752
dc.description.abstractDifferent types of interferon are widely used to treat hepatitis C virus (HCV) infection. Results obtained in vitro suggest that interferon inhibits internal ribosome entry site (IRES)-mediated translation of the HCV genome. To elucidate the possible effect of the nucleotide sequence of IRES on therapy outcome, we compared HCV isolates from patients with sustained response and non-response to interferon/ribavirin combination therapy. In 56 analyzed HCV isolates, nucleotide changes appeared strictly in the stem-loop IIIb region, the stem part from 243 nt to 248 nt, and the polypyrimidine-II region. The natural sequence variability of IRES in isolates of genotype 3a was significantly higher than in isolates of genotype 1b (p LT 0.05). The average number of nucleotide changes in genotype 3a correlated with response to therapy (p LT 0.05).en
dc.relationMinistry of Science and Environmental Protection of the Republic of Serbia [1430 10, 143011]
dc.rightsopenAccessen
dc.sourceArchives of biological sciencesen
dc.subjectHepatitis C virusen
dc.subjectinterferonen
dc.subjectinternal ribosome entry siteen
dc.subjectgenotypes 1b and 3aen
dc.titleSequence Variability At the Internal Ribosome Entry Site of the Hcv Genome in Relation to Therapy Outcomeen
dc.typearticleen
dcterms.abstractЈовановић-Ћупић Снежана; Благојевиц, Јелена; Стаменковић Горана; Симоновиц-Бабиц, Јасмина; Бозиц, Милена; Јесиц, Рада; Нозиц, Д.;
dc.citation.volume61
dc.citation.issue2
dc.citation.spage205
dc.citation.epage212
dc.identifier.wos000268316000007
dc.identifier.doi10.2298/ABS0901205J
dc.citation.rankM23


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