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dc.creatorMitić, Miloš
dc.creatorLukić, Iva
dc.creatorBozovic, Natalija
dc.creatorĐorđević, Jelena D.
dc.creatorAdžić, Miroslav
dc.date.accessioned2018-03-01T15:52:26Z
dc.date.available2018-03-01T15:52:26Z
dc.date.issued2015
dc.identifier.issn0895-8696 (print)
dc.identifier.issn1559-1166 (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/367
dc.description.abstractA growing body of evidence indicates that mitogen-activated protein kinase (MAPK) participates in various stress-induced responses and is considered to be one of the pathophysiological mechanisms in depression. Surprisingly, the effect of antidepressants on MAPKs is almost unexplored, particularly from the perspective of sexes. The present study investigates the cytoplasm-nuclear distribution of MAPK family, c-Jun N-terminal kinases (JNKs) 1, 2 and 3; extracellular signal-regulated kinases (ERKs) 1 and 2; and p38 kinases, as well as their phosphoisoforms in the hippocampus of chronically stressed female and male rats and upon chronic fluoxetine treatment. Additionally, we analysed crosstalk between MAPK signalling and depressive-like behaviour which correlated with brain-derived neurotrophic factor (BDNF) expression. Our results emphasize a gender-specific and compartment-dependent response of MAPKs to stress and fluoxetine. In females, stress decreased pp38 and pJNK and induced cytosolic retention of pERKs which reduced all nuclear pMAPKs. These changes correlated with altered BDNF expression and behaviour. Similarly, in males, stress decreased pp38 but promoted nuclear translocation of pJNKs and pERKs. These stress alterations of pMAPKs in males were not associated with BDNF expression and depressive-like behaviour. Fluoxetine treatment in stressed females upregulated whole pMAPK signalling particularly those in nucleus which was followed with BDNF expression and normalization of behaviour. In stressed males, fluoxetine affected only cytosolic pJNKs, while nuclear pMAPK signalling and BDNF expression were unaffected even though fluoxetine normalized behaviour. Overall, our results suggest existence of gender-specific mechanism of fluoxetine on nuclear pMAPK/BDNF signalling and depressive-like behaviour and reinforce the antidepressant dogma that females and males respond differently to certain antidepressants.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41029/RS//
dc.rightsrestrictedAccessen
dc.sourceJournal of Molecular Neuroscienceen
dc.subjectFluoxetineen
dc.subjectMAPK signallingen
dc.subjectGenderen
dc.subjectChronic stressen
dc.subjectHippocampusen
dc.titleFluoxetine Signature on Hippocampal MAPK Signalling in Sex-Dependent Manneren
dc.typearticleen
dcterms.abstractЛукиц, Ива; Митић Милош; Aджић Мирослав; Ђорђевић Јелена Д.; Бозовиц, Наталија;
dc.citation.volume55
dc.citation.issue2
dc.citation.spage335
dc.citation.epage346
dc.identifier.wos000348341500007
dc.identifier.doi10.1007/s12031-014-0328-1
dc.citation.rankM23
dc.identifier.pmid24841087
dc.identifier.scopus2-s2.0-84939566511


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