Early effects of gamma rays and protons on human melanoma cell viability and morphology
Аутори
Todorović, Danijela V.Petrović, Ivan M.
Todorović, M.
Cuttone, Giacomo
Ristić-Fira, Aleksandra
Чланак у часопису
Метаподаци
Приказ свих података о документуАпстракт
The effects of irradiation with gamma rays and protons on HTB140 human melanoma cell morphology and viability were analyzed. Exponentially growing cells were irradiated close to the Bragg peak maximum of the 62-MeV proton beam, as well as with (60)Co gamma rays, with doses ranging from 8 to 24 Gy. The overall cell morphology was unchanged 6 and 48 h after gamma irradiation, also showing a relatively weak cell-inactivation level. After exposure to proton beam, considerable changes in cell morphology followed by stronger cell inactivation were achieved. Proliferation capacity of irradiated cells significantly decreased in both experimental set-ups. Higher ionization level of protons with respect to gamma rays, representing the main physical difference between these two types of radiation, was also revealed on the cell membrane level through larger pro-apoptotic capacity of protons.
Кључне речи:
Apoptosis / cell morphology / gamma rays / melanoma cells / proliferation / protonsИзвор:
Journal of Microscopy, Oxford, 2008, 232, 3, 517-521
DOI: 10.1111/j.1365-2818.2008.02151.x
ISSN: 0022-2720
PubMed: 19094032
WoS: 000261253200018
Scopus: 2-s2.0-57449121824
Колекције
Институција/група
VinčaTY - JOUR AU - Todorović, Danijela V. AU - Petrović, Ivan M. AU - Todorović, M. AU - Cuttone, Giacomo AU - Ristić-Fira, Aleksandra PY - 2008 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3573 AB - The effects of irradiation with gamma rays and protons on HTB140 human melanoma cell morphology and viability were analyzed. Exponentially growing cells were irradiated close to the Bragg peak maximum of the 62-MeV proton beam, as well as with (60)Co gamma rays, with doses ranging from 8 to 24 Gy. The overall cell morphology was unchanged 6 and 48 h after gamma irradiation, also showing a relatively weak cell-inactivation level. After exposure to proton beam, considerable changes in cell morphology followed by stronger cell inactivation were achieved. Proliferation capacity of irradiated cells significantly decreased in both experimental set-ups. Higher ionization level of protons with respect to gamma rays, representing the main physical difference between these two types of radiation, was also revealed on the cell membrane level through larger pro-apoptotic capacity of protons. T2 - Journal of Microscopy, Oxford T1 - Early effects of gamma rays and protons on human melanoma cell viability and morphology VL - 232 IS - 3 SP - 517 EP - 521 DO - 10.1111/j.1365-2818.2008.02151.x ER -
@article{ author = "Todorović, Danijela V. and Petrović, Ivan M. and Todorović, M. and Cuttone, Giacomo and Ristić-Fira, Aleksandra", year = "2008", abstract = "The effects of irradiation with gamma rays and protons on HTB140 human melanoma cell morphology and viability were analyzed. Exponentially growing cells were irradiated close to the Bragg peak maximum of the 62-MeV proton beam, as well as with (60)Co gamma rays, with doses ranging from 8 to 24 Gy. The overall cell morphology was unchanged 6 and 48 h after gamma irradiation, also showing a relatively weak cell-inactivation level. After exposure to proton beam, considerable changes in cell morphology followed by stronger cell inactivation were achieved. Proliferation capacity of irradiated cells significantly decreased in both experimental set-ups. Higher ionization level of protons with respect to gamma rays, representing the main physical difference between these two types of radiation, was also revealed on the cell membrane level through larger pro-apoptotic capacity of protons.", journal = "Journal of Microscopy, Oxford", title = "Early effects of gamma rays and protons on human melanoma cell viability and morphology", volume = "232", number = "3", pages = "517-521", doi = "10.1111/j.1365-2818.2008.02151.x" }
Todorović, D. V., Petrović, I. M., Todorović, M., Cuttone, G.,& Ristić-Fira, A.. (2008). Early effects of gamma rays and protons on human melanoma cell viability and morphology. in Journal of Microscopy, Oxford, 232(3), 517-521. https://doi.org/10.1111/j.1365-2818.2008.02151.x
Todorović DV, Petrović IM, Todorović M, Cuttone G, Ristić-Fira A. Early effects of gamma rays and protons on human melanoma cell viability and morphology. in Journal of Microscopy, Oxford. 2008;232(3):517-521. doi:10.1111/j.1365-2818.2008.02151.x .
Todorović, Danijela V., Petrović, Ivan M., Todorović, M., Cuttone, Giacomo, Ristić-Fira, Aleksandra, "Early effects of gamma rays and protons on human melanoma cell viability and morphology" in Journal of Microscopy, Oxford, 232, no. 3 (2008):517-521, https://doi.org/10.1111/j.1365-2818.2008.02151.x . .