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dc.creatorPejić, Snežana
dc.creatorTodorović, Ana
dc.creatorStojiljković, Vesna
dc.creatorCvetković, Dragana
dc.creatorLucic, Nenad
dc.creatorRadojicic, Ratko M.
dc.creatorSaicic, Zorica S.
dc.creatorPajović, Snežana B.
dc.date.accessioned2018-03-01T20:31:58Z
dc.date.available2018-03-01T20:31:58Z
dc.date.issued2008
dc.identifier.issn0001-3765 (print)
dc.identifier.issn1678-2690 (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/3520
dc.description.abstractEpidemiological and experimental data point to involvement of oxygen derived radicals in the pathogenesis of gynecological disorders, as well as in cancer development. The objective of the present study was to examine changes ill activities and levels of copper/zinc superoxide dismutase (CuZnSOD) and lipid hydroperoxides (LOOH) in blood and endometrial tissue of patients diagnosed With uterine myoma, endometrial polypus, hyperplasia simplex, hyperplasia complex and adenocarcinoma endometrii. The results of our study have shown decreased SOD activities and unchanged SOD protein level in blood of all examined patients in comparison to healthy Subjects. Decrease of both SOD activity and level was Found in endometrium of patients with hyperplasia simplex, hyperplasia complex and adenocarcinoma in comparison to women with polypus or myoma. LOOH level was elevated in both tissues of patients with hyperplasia or adenocarcinoma in comparison to healthy Subjects or patients with benign diagnosis. Our findings suggest that the decrease in SOD activity and level, as well as the increase in LOOH level, in patients with gynecological disorders. render these patients more Susceptible to oxidative damage caused by reactive oxygen species (ROS). An imbalance in ROS formation and SOD level may be important in the pathogenesis and/or perpetuation of tissue damage in gynecological patients. Since evidence suggests that SOD may be a therapy target for cancer treatment, our findings provide a basis for further research and options for clinical applications.en
dc.relationMinistry of Science and Technology of the Republic of Serbia [143044B, 143035B]
dc.rightsopenAccessen
dc.sourceAnais de Academia Brasileira de Cienciasen
dc.subjectcopper/zinc superoxide dismutaseen
dc.subjectlipid hydroperoxidesen
dc.subjectuterine myomaen
dc.subjectendometrial polypusen
dc.subjectendometrial hyperplasiaen
dc.subjectendometrial adenocarcinomaen
dc.titleSuperoxide dismutase and lipid hydroperoxides in blood and endometrial tissue of patients with benign, hyperplastic and malignant endometriumen
dc.typearticleen
dcterms.abstractПејић Снежана; Тодоровић Aна; Стојиљковић Весна; Цветковиц, Драгана; Луциц, Ненад; Пајовиц, Снезана Б.; Радојициц, Ратко М.; Саициц, Зорица С.;
dc.citation.volume80
dc.citation.issue3
dc.citation.spage515
dc.citation.epage522
dc.identifier.wos000259122400011
dc.identifier.doi10.1590/S0001-37652008000300011
dc.citation.rankM22
dc.identifier.pmid18797802
dc.identifier.scopus2-s2.0-51749113114
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs//bitstream/id/12480/3516.pdf


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