Superoxide dismutase and lipid hydroperoxides in blood and endometrial tissue of patients with benign, hyperplastic and malignant endometrium
2008
Аутори
Pejić, SnežanaTodorović, Ana
Stojiljković, Vesna
Cvetković, Dragana
Lucic, Nenad
Radojicic, Ratko M.
Saičić, Zorica S.
Pajović, Snežana B.
Чланак у часопису
Метаподаци
Приказ свих података о документуАпстракт
Epidemiological and experimental data point to involvement of oxygen derived radicals in the pathogenesis of gynecological disorders, as well as in cancer development. The objective of the present study was to examine changes ill activities and levels of copper/zinc superoxide dismutase (CuZnSOD) and lipid hydroperoxides (LOOH) in blood and endometrial tissue of patients diagnosed With uterine myoma, endometrial polypus, hyperplasia simplex, hyperplasia complex and adenocarcinoma endometrii. The results of our study have shown decreased SOD activities and unchanged SOD protein level in blood of all examined patients in comparison to healthy Subjects. Decrease of both SOD activity and level was Found in endometrium of patients with hyperplasia simplex, hyperplasia complex and adenocarcinoma in comparison to women with polypus or myoma. LOOH level was elevated in both tissues of patients with hyperplasia or adenocarcinoma in comparison to healthy Subjects or patients with benign diagnosi...s. Our findings suggest that the decrease in SOD activity and level, as well as the increase in LOOH level, in patients with gynecological disorders. render these patients more Susceptible to oxidative damage caused by reactive oxygen species (ROS). An imbalance in ROS formation and SOD level may be important in the pathogenesis and/or perpetuation of tissue damage in gynecological patients. Since evidence suggests that SOD may be a therapy target for cancer treatment, our findings provide a basis for further research and options for clinical applications.
Кључне речи:
copper/zinc superoxide dismutase / lipid hydroperoxides / uterine myoma / endometrial polypus / endometrial hyperplasia / endometrial adenocarcinomaИзвор:
Anais de Academia Brasileira de Ciencias, 2008, 80, 3, 515-522Финансирање / пројекти:
- Ministry of Science and Technology of the Republic of Serbia [143044B, 143035B]
DOI: 10.1590/S0001-37652008000300011
ISSN: 0001-3765; 1678-2690
PubMed: 18797802
WoS: 000259122400011
Scopus: 2-s2.0-51749113114
Колекције
Институција/група
VinčaTY - JOUR AU - Pejić, Snežana AU - Todorović, Ana AU - Stojiljković, Vesna AU - Cvetković, Dragana AU - Lucic, Nenad AU - Radojicic, Ratko M. AU - Saičić, Zorica S. AU - Pajović, Snežana B. PY - 2008 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3520 AB - Epidemiological and experimental data point to involvement of oxygen derived radicals in the pathogenesis of gynecological disorders, as well as in cancer development. The objective of the present study was to examine changes ill activities and levels of copper/zinc superoxide dismutase (CuZnSOD) and lipid hydroperoxides (LOOH) in blood and endometrial tissue of patients diagnosed With uterine myoma, endometrial polypus, hyperplasia simplex, hyperplasia complex and adenocarcinoma endometrii. The results of our study have shown decreased SOD activities and unchanged SOD protein level in blood of all examined patients in comparison to healthy Subjects. Decrease of both SOD activity and level was Found in endometrium of patients with hyperplasia simplex, hyperplasia complex and adenocarcinoma in comparison to women with polypus or myoma. LOOH level was elevated in both tissues of patients with hyperplasia or adenocarcinoma in comparison to healthy Subjects or patients with benign diagnosis. Our findings suggest that the decrease in SOD activity and level, as well as the increase in LOOH level, in patients with gynecological disorders. render these patients more Susceptible to oxidative damage caused by reactive oxygen species (ROS). An imbalance in ROS formation and SOD level may be important in the pathogenesis and/or perpetuation of tissue damage in gynecological patients. Since evidence suggests that SOD may be a therapy target for cancer treatment, our findings provide a basis for further research and options for clinical applications. T2 - Anais de Academia Brasileira de Ciencias T1 - Superoxide dismutase and lipid hydroperoxides in blood and endometrial tissue of patients with benign, hyperplastic and malignant endometrium VL - 80 IS - 3 SP - 515 EP - 522 DO - 10.1590/S0001-37652008000300011 ER -
@article{ author = "Pejić, Snežana and Todorović, Ana and Stojiljković, Vesna and Cvetković, Dragana and Lucic, Nenad and Radojicic, Ratko M. and Saičić, Zorica S. and Pajović, Snežana B.", year = "2008", abstract = "Epidemiological and experimental data point to involvement of oxygen derived radicals in the pathogenesis of gynecological disorders, as well as in cancer development. The objective of the present study was to examine changes ill activities and levels of copper/zinc superoxide dismutase (CuZnSOD) and lipid hydroperoxides (LOOH) in blood and endometrial tissue of patients diagnosed With uterine myoma, endometrial polypus, hyperplasia simplex, hyperplasia complex and adenocarcinoma endometrii. The results of our study have shown decreased SOD activities and unchanged SOD protein level in blood of all examined patients in comparison to healthy Subjects. Decrease of both SOD activity and level was Found in endometrium of patients with hyperplasia simplex, hyperplasia complex and adenocarcinoma in comparison to women with polypus or myoma. LOOH level was elevated in both tissues of patients with hyperplasia or adenocarcinoma in comparison to healthy Subjects or patients with benign diagnosis. Our findings suggest that the decrease in SOD activity and level, as well as the increase in LOOH level, in patients with gynecological disorders. render these patients more Susceptible to oxidative damage caused by reactive oxygen species (ROS). An imbalance in ROS formation and SOD level may be important in the pathogenesis and/or perpetuation of tissue damage in gynecological patients. Since evidence suggests that SOD may be a therapy target for cancer treatment, our findings provide a basis for further research and options for clinical applications.", journal = "Anais de Academia Brasileira de Ciencias", title = "Superoxide dismutase and lipid hydroperoxides in blood and endometrial tissue of patients with benign, hyperplastic and malignant endometrium", volume = "80", number = "3", pages = "515-522", doi = "10.1590/S0001-37652008000300011" }
Pejić, S., Todorović, A., Stojiljković, V., Cvetković, D., Lucic, N., Radojicic, R. M., Saičić, Z. S.,& Pajović, S. B.. (2008). Superoxide dismutase and lipid hydroperoxides in blood and endometrial tissue of patients with benign, hyperplastic and malignant endometrium. in Anais de Academia Brasileira de Ciencias, 80(3), 515-522. https://doi.org/10.1590/S0001-37652008000300011
Pejić S, Todorović A, Stojiljković V, Cvetković D, Lucic N, Radojicic RM, Saičić ZS, Pajović SB. Superoxide dismutase and lipid hydroperoxides in blood and endometrial tissue of patients with benign, hyperplastic and malignant endometrium. in Anais de Academia Brasileira de Ciencias. 2008;80(3):515-522. doi:10.1590/S0001-37652008000300011 .
Pejić, Snežana, Todorović, Ana, Stojiljković, Vesna, Cvetković, Dragana, Lucic, Nenad, Radojicic, Ratko M., Saičić, Zorica S., Pajović, Snežana B., "Superoxide dismutase and lipid hydroperoxides in blood and endometrial tissue of patients with benign, hyperplastic and malignant endometrium" in Anais de Academia Brasileira de Ciencias, 80, no. 3 (2008):515-522, https://doi.org/10.1590/S0001-37652008000300011 . .